Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol.
Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol.
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DOI：
10.1371/journal.pone.0008127
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发表时间：
2009-12-02
期刊：
影响因子：
3.7
通讯作者：
Lachenmeier DW
中科院分区：
文献类型：
--
作者：
Leitz J;Kuballa T;Rehm J;Lachenmeier DW
邻苯二甲酸酯是一种具有广泛应用领域的合成化合物。例如，它们被用作PVC塑料和食品包装中的增塑剂，或添加到个人护理产品中。邻苯二甲酸二乙酯（DEP）可用于使酒精变性，例如用于美容目的。邻苯二甲酸酯的公共卫生问题包括致癌、致畸、肝毒性和内分泌影响。本研究的目的是开发和验证一种测定酒精样品中邻苯二甲酸盐的方法，并为此类产品的消费者提供风险评估。通过改变萃取溶剂类型（环己烷、正己烷、1,1,2-三氯三氟乙烷）、萃取溶剂/样品体积比（1∶1 ~ 50∶1）和萃取次数（1 ~ 10次），优化液液萃取工艺。以1,1,2-三氯三氟乙烷为萃取溶剂，萃取溶剂体积比为10∶1，两次萃取，提取率为99.9%。定量采用氘化内标气相色谱/质谱法。调查的样本是来自不同国家的酒精饮料和未记录的酒精产品（n = 257）。来自立陶宛的两个未记录的酒精样品含有浓度分别为608毫克/升和210毫克/升的邻苯二甲酸二乙酯。从动物实验中得出，邻苯二甲酸盐阳性未记录的酒精的消耗量将超过可耐受的每日摄入量。两个阳性样本都被标记为化妆品酒精，但显然是供人类食用的。DEP似乎不适合作为变性剂，因为它对乙醇的感官特性没有影响。鉴于我们的研究结果，DEP可能会被人类消耗在未记录的酒精中，应考虑禁止其作为变性剂使用。
Phthalates are synthetic compounds with a widespread field of applications. For example, they are used as plasticizers in PVC plastics and food packaging, or are added to personal care products. Diethyl phthalate (DEP) may be used to denature alcohol, e.g., for cosmetic purposes. Public health concerns of phthalates include carcinogenic, teratogenic, hepatotoxic and endocrine effects. The aim of this study was to develop and validate a method for determining phthalates in alcohol samples and to provide a risk assessment for consumers of such products. A liquid-liquid extraction procedure was optimized by varying the following parameters: type of extraction solvent (cyclohexane, n-hexane, 1,1,2-trichlorotrifluoroethane), the ratio extraction solvent/sample volume (1∶1 to 50∶1) and the number of extraction repetitions (1–10). The best extraction yield (99.9%) was achieved with the solvent 1,1,2-trichlorotrifluoroethane, an extraction solvent volume/sample volume ratio of 10∶1 and a double extraction. For quantification, gas chromatography/mass spectrometry with deuterated internal standards was used. The investigated samples were alcoholic beverages and unrecorded alcohol products from different countries (n = 257). Two unrecorded alcohol samples from Lithuania contained diethyl phthalate in concentrations of 608 mg/L and 210 mg/L. The consumption of the phthalate-positive unrecorded alcohols would exceed tolerable daily intakes as derived from animal experiments. Both positive samples were labelled as cosmetic alcohol, but had clearly been offered for human consumption. DEP seems to be unsuitable as a denaturing agent as it has no effect on the organoleptic properties of ethanol. In light of our results that DEP might be consumed by humans in unrecorded alcohols, the prohibition of its use as a denaturing agent should be considered.
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作者：
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DOI：
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影响因子：
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