Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.
Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.
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DOI：
10.1001/jamainternmed.2017.5038
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发表时间：
2018-01-01
影响因子：
39
通讯作者：
EARTH Study Team
中科院分区：
文献类型：
--
作者：
Chiu YH;Williams PL;Gillman MW;Gaskins AJ;Mínguez-Alarcón L;Souter I;Toth TL;Ford JB;Hauser R;Chavarro JE;EARTH Study Team
动物实验表明，摄入环境相关浓度的农药混合物会减少活产后代的数量。人类是否也是如此尚不清楚。旨在研究水果和蔬菜中农药残留（FV）的孕前摄入量与辅助生殖技术（ART）治疗不孕症的结果之间的关系。这项分析包括 325 名女性，她们在教学医院的生育中心完成了饮食评估，随后在环境与生殖健康 (EARTH) 前瞻性队列研究（2007-2016 年）中接受了 541 个 ART 周期。我们根据美国农业部的监测数据，使用经过验证的方法将 FV 分为高农药残留和低农药残留。使用聚类加权广义估计方程来分析高和低农药残留 FV 摄入量与 ART 结果的关联。每个治疗周期的临床妊娠和活产的调整概率。在 325 名参与者中（平均 [SD] 年龄，35.1 [4.0] 岁；体重指数，24.1 [4.3]），高和低农药残留 FV 的平均 (SD) 摄入量分别为 1.7 (1.0) 和 2.8 (1.6) 份/天。大量摄入高农药残留 FV 与临床妊娠和活产概率较低有关。与高农药 FV 摄入量最低四分位数（<1.0 份/天）的女性相比，最高四分位数（≥ 2.3 份/天）的女性临床妊娠概率低 18%（95% CI，5%–30%），活产概率低 26%（95% CI，13%–37%）。低农药残留 FV 的摄入量与 ART 的结果没有显着相关。高农药残留 FV 的消费量较高与接受 ART 治疗不孕症后妊娠和活产的可能性较低有关。这些数据表明，人类典型接触范围内的膳食农药接触可能与不良生殖后果有关。
Animal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown. To examine the association of preconception intake of pesticide residues in fruits and vegetables (FVs) with outcomes of infertility treatment with assisted reproductive technologies (ART). This analysis included 325 women who completed a diet assessment and subsequently underwent 541 ART cycles in the Environment and Reproductive Health (EARTH) prospective cohort study (2007–2016) at a fertility center at a teaching hospital. We categorized FVs as having high or low pesticide residues using a validated method based on surveillance data from the US Department of Agriculture. Cluster-weighted generalized estimating equations were used to analyze associations of high– and low–pesticide residue FV intake with ART outcomes. Adjusted probabilities of clinical pregnancy and live birth per treatment cycle. In the 325 participants (mean [SD] age, 35.1 [4.0] y; body mass index, 24.1 [4.3]), mean (SD) intakes of high– and low–pesticide residue FVs were 1.7 (1.0) and 2.8 (1.6) servings/d, respectively. Greater intake of high–pesticide residue FVs was associated with a lower probability of clinical pregnancy and live birth. Compared with women in the lowest quartile of high-pesticide FV intake (<1.0 servings/d), women in the highest quartile (≥ 2.3 servings/d) had 18% (95% CI, 5%–30%) lower probability of clinical pregnancy and 26% (95% CI, 13%–37%) lower probability of live birth. Intake of low–pesticide residue FVs was not significantly related to ART outcomes. Higher consumption of high–pesticide residue FVs was associated with lower probabilities of pregnancy and live birth following infertility treatment with ART. These data suggest that dietary pesticide exposure within the range of typical human exposure may be associated with adverse reproductive consequences.
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影响因子：
3.3
作者：
Messerlian C;Gaskins AJ
通讯作者：
Gaskins AJ
影响因子：
10.4
作者：
Greenlee AR;Ellis TM;Berg RL
通讯作者：
Berg RL
影响因子：
6.7
作者：
Chavarro, Jorge E.;Ehrlich, Shelley;Colaci, Daniela S.;Wright, Diane L.;Toth, Thomas L.;Petrozza, John C.;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
5
作者：
Bell, EM;Hertz-Picciotto, I;Beaumont, JJ
通讯作者：
Beaumont, JJ
影响因子：
10.4
作者：
Brantsaeter, Anne Lise;Torjusen, Hanne;Haugen, Margaretha
通讯作者：
Haugen, Margaretha