The Effect of RANKL/OPG Balance on Reducing Implant Complications.
The Effect of RANKL/OPG Balance on Reducing Implant Complications.
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DOI：
10.3390/jfb8040042
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发表时间：
2017-09-22
影响因子：
4.8
通讯作者：
Yang XB
中科院分区：
文献类型：
--
作者：
Kapasa ER;Giannoudis PV;Jia X;Hatton PV;Yang XB
尽管种植体在牙科和整形外科领域取得了巨大的成功，但仍有许多挑战需要克服。由于感染、假体松动和不愈合导致的假体失败仍然是最臭名昭著的例子。骨折愈合和骨修复的级联反应，特别是植入物的存在，是复杂的，因为它涉及多方面的免疫反应以及复杂的骨形成和重塑过程。骨质流失是一个严重的临床问题，经常伴有慢性炎症，说明炎症与骨质侵蚀之间存在复杂的关系。促炎因子的作用在启动和维持破骨细胞生成中起着重要作用，从而导致破骨细胞的骨吸收。这是因为核因子κ b配体受体激活因子（RANKL）和骨保护素（OPG）之间的相对比例被破坏，而骨保护素是调节骨修复和重塑的核心。本文旨在为骨重塑过程、骨植入后的级联修复以及相关并发症提供背景资料。此外，目前的临床解决方案可以通过内部或外部机制影响骨形成将被描述。这些通过靶向RANKL/OPG比率来治疗骨溶解的有效方法可能对减少未来相关种植体失败的发生率至关重要。
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion. The effects of pro-inflammatory factors play a significant role in initiating and maintaining osteoclastogenesis that results in bone resorption by osteoclasts. This is because there is a disruption of the relative ratio between Receptor Activator of Nuclear Factor κB-Ligand (RANKL) and osteoprotegerin (OPG), which is central to modulating bone repair and remodelling. This review aims to provide a background to the bone remodelling process, the bone repair cascade post-implantation, and the associated complications. Furthermore, current clinical solutions that can influence bone formation via either internal or extrinsic mechanisms will be described. These efficacious treatments for osteolysis via targeting the RANKL/OPG ratio may be crucial to reducing the incidence of related implant failures in the future.
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DOI：
10.1302/0301-620x.83b6.10905
发表时间：
2001-08-01
影响因子：
--
作者：
Haynes, DR;Crotti, TN;Findlay, DM
通讯作者：
Findlay, DM
影响因子：
4.9
作者：
Cadosch, Dieter;Al-Mushaiqri, Mohamed S.;Filgueira, Luis
通讯作者：
Filgueira, Luis
影响因子：
2.8
作者：
Cadosch, Dieter;Chan, Erwin;Filgueira, Luis
通讯作者：
Filgueira, Luis
影响因子：
4.1
作者：
Crotti TN;Dharmapatni AA;Alias E;Haynes DR
通讯作者：
Haynes DR
影响因子：
6.2
作者：
Bekker, PJ;Holloway, D;Dunstan, CR
通讯作者：
Dunstan, CR