Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning.
Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning.
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DOI：
10.1016/j.neuro.2017.08.005
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发表时间：
2017-09
期刊：
影响因子：
3.4
通讯作者：
Engel SM
中科院分区：
文献类型：
--
作者：
Furlong MA;Barr DB;Wolff MS;Engel SM
之前几项关于拟除虫菊酯生物标志物和行为的研究已经报道了同时存在的拟除虫菊酯水平与儿童不良行为问题之间的关联。一项地理空间研究报告了产前接触拟除虫菊酯与自闭症之间的联系。然而，产前拟除虫菊酯生物标志物与儿童行为之间的关联尚不清楚。西奈山儿童环境健康中心是一个预期出生的队列，在怀孕期间使用尿拟除虫菊酯生物标记物，并在4、6和7-9岁时进行行为测量。初产妇女是在1998-2002年间登记的。162对具有完整暴露和行为结局数据的母子对，调查了产前可检测到的拟除虫菊酯代谢物水平与儿童行为评估系统得分和执行功能行为评定量表之间的关系。总体而言，拟除虫菊酯代谢物的检测频率很低(<；30%)。在纵向混合模型中，孕期可检测到的3-PBA水平与较差的内化(β−4.50，95%CI−8.05，−0.95)、抑郁(β−3.21，95%CI−6.38，−0.05)、躯体化(β−3.22，95%CI−6.38，−0.06)、行为调节(β−3.59，95%CI−6.97，−0.21)、情绪控制(β−3.35，95%CI−6.58)、−0.12)、移动(β−3.42，95%CI−6.73，−0.11)和监控(β−4.08，95%CI−7.07，−1.08)量表。可检测到的顺式-DCCA水平与较差的外部性(β−4.74，95%CI−9.37，−0.10)、行为问题(β−5.35，95%CI−9.90，−0.81)、行为调节(β−6.42，95%CI−11.39，−1.45)和抑制性控制(β−7.20，95%CI−12.00，−2.39)相关。尽管拟除虫菊酯代谢物的检测频率很低，但我们发现了提示证据，即产前暴露于3-PBA和顺式-DCCA可能与各种行为和执行功能缺陷有关。
Several previous studies of pyrethroid biomarkers and behavior have reported associations between concurrent pyrethroid levels and adverse behavioral problems in children. One geospatial study reported associations between prenatal exposure to pyrethroids and autism. However, the association between prenatal pyrethroid biomarkers and childhood behavior is unknown. The Mount Sinai Children’s Environmental Health Center is a prospective birth cohort with urinary pyrethroid biomarkers during pregnancy and behavioral measurements at 4, 6, and 7–9 years of age. Primiparous women were enrolled between 1998–2002. 162 mother/child pairs with complete exposure and behavioral outcomes data were used to investigate associations between detectable levels of prenatal pyrethroid metabolites and scores on the Behavioral Assessment System for Children and the Behavior Rating Inventory of Executive Function. Overall, detection frequencies of pyrethroid metabolites were low (< 30%). In longitudinal mixed models, detectable levels of 3-PBA during pregnancy were associated with worse Internalizing (β −4.50, 95% CI −8.05, −0.95), Depression (β −3.21, 95% CI −6.38, −0.05), Somatization (β −3.22, 95% CI −6.38, −0.06), Behavioral Regulation (β −3.59, 95% CI −6.97, −0.21), Emotional Control (β −3.35, 95% CI −6.58, −0.12), Shifting (β −3.42, 95% CI −6.73, −0.11), and Monitoring (β −4.08, 95% CI −7.07, −1.08) scales. Detectable levels of cis-DCCA were associated with worse Externalizing (β −4.74, 95% CI −9.37, −0.10), Conduct Problems (β −5.35, 95% CI −9.90, −0.81), Behavioral Regulation (β −6.42, 95% CI −11.39, −1.45), and Inhibitory Control (β −7.20, 95% CI −12.00, −2.39). Although detection frequencies of pyrethroid metabolites were low, we found suggestive evidence that prenatal exposure to 3-PBA and cis-DCCA may be associated with a variety of behavioral and executive functioning deficits.
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在多种族的城市队列中，怀孕期间室内农药接触。
影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
影响因子：
8.3
作者：
Barr, DB;Allen, R;Needham, LL
通讯作者：
Needham, LL
DOI：
10.1038/sj.jea.7500322
发表时间：
2004-05-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Bravo, R;Caltabiano, LM;Barr, DB
通讯作者：
Barr, DB
影响因子：
10.4
作者：
Barr DB;Olsson AO;Wong LY;Udunka S;Baker SE;Whitehead RD;Magsumbol MS;Williams BL;Needham LL
通讯作者：
Needham LL
影响因子：
8.3
作者：
Furlong MA;Herring A;Buckley JP;Goldman BD;Daniels JL;Engel LS;Wolff MS;Chen J;Wetmur J;Barr DB;Engel SM
通讯作者：
Engel SM