Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One.
Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One.
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DOI：
10.1186/1465-9921-11-8
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发表时间：
2010-01-21
影响因子：
5.8
通讯作者：
ISAAC Phase One Study Group
中科院分区：
文献类型：
--
作者：
Asher MI;Stewart AW;Mallol J;Montefort S;Lai CK;Aït-Khaled N;Odhiambo J;ISAAC Phase One Study Group
儿童哮喘和过敏症国际研究（ISAAC）第一阶段显示，哮喘、鼻结膜炎和湿疹症状的患病率在世界范围内存在很大差异，各国之间高达10至20倍。生态分析进行了ISAAC第一阶段的数据，以探讨可能导致这些变化的因素，并在这里进行了总结和审查。在ISAAC第一阶段，对56个国家155个中心463，801名13 - 14岁儿童和38个国家91个中心257，800名6-7岁儿童的研究估计了过去12个月内哮喘、鼻结膜炎和湿疹症状的流行率。在症状患病率与以下因素之间进行生态分析：人均国民生产总值（GNP），食物摄入量，免疫接种率，结核病通知，气候因素，烟草消费，花粉，抗生素销售，扑热息痛销售和室外空气污染。所有这三种疾病的症状患病率与GNP、反式脂肪酸、扑热息痛和女性吸烟呈正相关，与植物源性食物、花粉、免疫接种、结核病通知、空气污染和男性吸烟呈负相关。这些关联的程度很小，但在不同条件下的方向是一致的。气候和抗生素销售与症状患病率之间存在混合关联。这些相关性的潜在因果关系需要进一步研究。从政策角度来看，防止这些疾病发展的因素，或在人口水平上缺乏正相关性的因素，可能与关注积极的风险因素一样重要。基于小关联的干预措施可能会带来巨大的公共卫生效益。
The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution. Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence. The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.
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影响因子：
4.9
作者：
Anderson, H. Ross;Ruggles, Ruth;Weiland, Stephan K.
通讯作者：
Weiland, Stephan K.
影响因子：
24.3
作者：
Newson, RB;Shaheen, SO;Burney, PGJ
通讯作者：
Burney, PGJ
影响因子：
10.4
作者：
Brunekreef B;Stewart AW;Anderson HR;Lai CK;Strachan DP;Pearce N;ISAAC Phase 3 Study Group
通讯作者：
ISAAC Phase 3 Study Group
影响因子：
168.9
作者：
Beasley, R;Keil, U;Williams, HC
通讯作者：
Williams, HC
影响因子：
6.1
作者：
Riedler, J;Eder, W;Schreuer, M
通讯作者：
Schreuer, M