Review of pesticide urinary biomarker measurements from selected US EPA children's observational exposure studies.
Review of pesticide urinary biomarker measurements from selected US EPA children's observational exposure studies.
复制标题
从某些美国EPA儿童观察暴露研究中回顾农药尿生物标志物测量。
DOI：
10.3390/ijerph8051727
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发表时间：
2011-05
影响因子：
--
通讯作者：
Sheldon LS
中科院分区：
文献类型：
--
作者：
Egeghy PP;Cohen Hubal EA;Tulve NS;Melnyk LJ;Morgan MK;Fortmann RC;Sheldon LS
儿童接触到来自室外和室内的各种农药。在过去的十年里，环境保护署进行或资助了几项研究，调查儿童接触有机磷和拟除虫菊酯杀虫剂的情况以及影响他们接触的因素。从这些研究中得到的尿代谢物浓度测量结果在这里被合并，以确定趋势、空间和时间模式以及需要进一步研究的领域。也就是说，给出了毒死蜱（3,5,6-三氯-2-吡啶醇或TCPy）、二嗪农（2-异丙基-6-甲基-4-嘧啶醇或IMP）和氯菊酯（3-苯氧苯甲酸或3- pba）的代谢物浓度。还提供了描述人体吸收和消除的动力学参数的信息，以帮助解释。与TCPy相比，3-PBA和IMP的代谢物浓度在研究中变化更大，TCPy的浓度比3-PBA的浓度高一个数量级。所有代谢物的时间变异性都很高，尿液3-PBA浓度随时间的变化比TCPy浓度稍微一致。尿液生物标志物水平仅提供有限的应用证据。所观察到的尿代谢物水平与农药摄入量估计值之间的关系可能受到每种暴露途径对总摄入量的贡献差异的影响，这可能因暴露强度和个体而异。
Children are exposed to a wide variety of pesticides originating from both outdoor and indoor sources. Several studies were conducted or funded by the EPA over the past decade to investigate children’s exposure to organophosphate and pyrethroid pesticides and the factors that impact their exposures. Urinary metabolite concentration measurements from these studies are consolidated here to identify trends, spatial and temporal patterns, and areas where further research is required. Namely, concentrations of the metabolites of chlorpyrifos (3,5,6-trichloro-2-pyridinol or TCPy), diazinon (2-isopropyl-6-methyl-4-pyrimidinol or IMP), and permethrin (3-phenoxybenzoic acid or 3-PBA) are presented. Information on the kinetic parameters describing absorption and elimination in humans is also presented to aid in interpretation. Metabolite concentrations varied more dramatically across studies for 3-PBA and IMP than for TCPy, with TCPy concentrations about an order of magnitude higher than the 3-PBA concentrations. Temporal variability was high for all metabolites with urinary 3-PBA concentrations slightly more consistent over time than the TCPy concentrations. Urinary biomarker levels provided only limited evidence of applications. The observed relationships between urinary metabolite levels and estimates of pesticide intake may be affected by differences in the contribution of each exposure route to total intake, which may vary with exposure intensity and across individuals.
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影响因子：
7.4
作者：
Beeson, MD;Driskell, WJ;Barr, DB
通讯作者：
Barr, DB
影响因子：
1.8
作者：
EADSFORTH, CV;BRAGT, PC;VANSITTERT, NJ
通讯作者：
VANSITTERT, NJ
影响因子：
10.4
作者：
Adgate, JL;Barr, DB;Sexton, K
通讯作者：
Sexton, K
DOI：
10.1038/sj.jea.7500261
发表时间：
2003-03-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Clayton, CA;Pellizzari, ED;Sefton, K
通讯作者：
Sefton, K
DOI：
10.1080/15459620590923343
发表时间：
2005-03-01
影响因子：
2
作者：
Coble, J;Arbuckle, T;Doserneci, M
通讯作者：
Doserneci, M