Successful treatment of bacterial infection hinders development of acquired immunity.
Successful treatment of bacterial infection hinders development of acquired immunity.
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DOI：
10.4049/jimmunol.0900772
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发表时间：
2009-07-15
期刊：
影响因子：
--
通讯作者：
McSorley SJ
中科院分区：
文献类型：
--
作者：
Griffin A;Baraho-Hassan D;McSorley SJ
抗生素通常用于控制细菌感染，但很少研究成功治疗后获得性免疫力的获得。我们开发了一个模型，可以在伤寒抗生素治疗期间和之后可视化获得性免疫。在抗生素治疗的小鼠中，病原体特异性体液和细胞免疫反应迅速激活，但在成功的抗生素治疗后无法持续，并且不能对继发感染提供保护。与此形成鲜明对比的是，在活疫苗株 (LVS) 免疫后的几周内，病原体特异性 Th1 和抗体反应就成熟了。抗生素治疗后保护性免疫的缺陷可以通过在抗生素治疗期间施用鞭毛蛋白来克服。因此，保护性免疫的发展受到快速治疗性消除细菌的阻碍，但可以通过提供额外的炎症和/或抗原刺激来克服。
Antibiotics are routinely used to control bacterial infection but the acquisition of acquired immunity following successful treatment has rarely been examined. We developed a model that allows visualization of acquired immunity during and following antibiotic treatment of typhoid. Pathogen-specific humoral and cellular immune responses were activated rapidly in antibiotic-treated mice but were not sustained after successful antibiotic treatment and did not confer protection to secondary infection. In marked contrast, pathogen-specific Th1 and antibody responses matured over several weeks following immunization with a live vaccine strain (LVS). The deficiency in protective immunity following antibiotic treatment could be overcome by administering flagellin during antibiotic therapy. Thus, development of protective immunity is hindered by rapid therapeutic elimination of bacteria but can be overcome by providing additional inflammatory and/or antigenic stimuli.
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