Prolinks: a database of protein functional linkages derived from coevolution.

Prolinks: a database of protein functional linkages derived from coevolution.
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DOI:
10.1186/gb-2004-5-5-r35
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发表时间:
2004
期刊:
影响因子:
12.3
通讯作者:
Eisenberg D
Eisenberg D
中科院分区:
生物学1区
文献类型:
--
作者:
Bowers PM;Pellegrini M;Thompson MJ;Fierro J;Yeates TO;Eisenberg D

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四种推断蛋白质功能和联系的方法被结合在一个单一的数据库Prolinks中,该数据库涵盖了83种生物,包括1000万个高可信度的联系。全基因组测序的出现导致了推断蛋白质功能和联系的方法。我们将四种这样的算法(系统发育谱、罗塞塔石碑、基因邻居和基因集群)结合在一个数据库中——Prolinks——涵盖了83种生物体,包括1000万个高可信度链接。Proteome Navigator工具允许用户交互式地浏览预测的链接网络,并提供来自公共数据库的伴随注释。Prolinks数据库和蛋白质组导航工具可在线使用。
Four methods that infer protein function and linkages have been combined in a single database, Prolinks, which spans 83 organisms and includes 10 million high-confidence links. The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database - Prolinks - that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at .
基于原核基因组组织的结核分枝杆菌中蛋白质功能和蛋白质链接的推断:一种合并的计算方法。
DOI: 10.1186/gb-2003-4-9-r59
发表时间: 2003
期刊: GENOME BIOLOGY
影响因子: 12.3
作者:
Strong, Michael;Mallick, Parag;Pellegrini, Matteo;Thompson, Michael J;Eisenberg, David
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