Cell collectivity regulation within migrating cell cluster during Kupffer's vesicle formation in zebrafish.
Cell collectivity regulation within migrating cell cluster during Kupffer's vesicle formation in zebrafish.
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DOI：
10.3389/fcell.2015.00027
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发表时间：
2015
影响因子：
5.5
通讯作者：
Bessho Y
中科院分区：
文献类型：
--
作者：
Matsui T;Ishikawa H;Bessho Y
尽管细胞粘附被认为可以将细胞紧紧固定，但相互粘附的细胞可以定向迁移。这种群体行为被称为“集体细胞迁移”，在正常发育、伤口愈合和癌症侵袭过程中观察到。在集体细胞迁移的几个模型系统中，细胞粘附分子的功能丧失导致细胞群迁移的延迟或抑制，但不会导致细胞群的解离，这表明细胞保持组装成单个细胞簇（称为“细胞集体性”）的机制在很大程度上仍然未知。在Kupffer囊泡（KV，斑马鱼的偏侧器官）的形成过程中，KV祖细胞形成簇并一起向植物极迁移。重要的是，在这种集体细胞迁移的模型系统中，细胞粘附分子或信号组分的敲低导致细胞集体性的失败。在这篇综述中，我们总结了最近的研究结果在KV祖细胞的集体迁移过程中的细胞集体调控，并描述了我们目前的理解细胞集体迁移过程中是如何调节的。
Although cell adhesion is thought to fasten cells tightly, cells that adhere to each other can migrate directionally. This group behavior, called “collective cell migration,” is observed during normal development, wound healing, and cancer invasion. Loss-of-function of cell adhesion molecules in several model systems of collective cell migration results in delay or inhibition of migration of cell groups but does not lead to dissociation of the cell groups, suggesting that mechanisms of cells staying assembled as a single cell cluster, termed as “cell collectivity,” remain largely unknown. During the formation of Kupffer's vesicle (KV, an organ of laterality in zebrafish), KV progenitors form a cluster and migrate together toward the vegetal pole. Importantly, in this model system of collective cell migration, knockdown of cell adhesion molecules or signal components leads to failure of cell collectivity. In this review, we summarize recent findings in cell collectivity regulation during collective migration of KV progenitor cells and describe our current understanding of how cell collectivity is regulated during collective cell migration.
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影响因子：
11.8
作者：
Compagnon, Julien;Barone, Vanessa;Heisenberg, Carl-Philipp
通讯作者：
Heisenberg, Carl-Philipp
影响因子：
2.5
作者：
Babb, SG;Barnett, J;Marrs, JA
通讯作者：
Marrs, JA
影响因子：
64.8
作者：
Essner, JJ;Vogan, KJ;Brueckner, M
通讯作者：
Brueckner, M
影响因子：
9.2
作者：
Amack, JD;Yost, HJ
通讯作者：
Yost, HJ
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG