Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.
Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.
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DOI：
10.1038/s41467-021-23064-5
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发表时间：
2021-05-18
影响因子：
16.6
通讯作者：
Neumann ID
中科院分区：
文献类型：
--
作者：
Oliveira VEM;Lukas M;Wolf HN;Durante E;Lorenz A;Mayer AL;Bludau A;Bosch OJ;Grinevich V;Egger V;de Jong TR;Neumann ID
与雄性大鼠相比，处女雌性大鼠的攻击性很少被研究。在这里，我们建立了一个大鼠模型，增强攻击性的女性使用社会隔离和攻击性训练相结合，专门调查参与的催产素（OXT）和精氨酸加压素（AVP）系统内的外侧隔（LS）。使用神经药理学，光遗传学，化学遗传学以及微透析方法，我们发现，增强腹侧LS（vLS）内的OXT释放，结合减少背侧LS（dLS）内的AVP释放，需要在雌性大鼠的侵略。因此，增加活动的推定OXT受体阳性神经元的vLS，和减少活动的推定AVP受体阳性神经元的dLS，可能是潜在的攻击雌性大鼠。最后，体外激活vLS中的OXT受体增加了dLS神经元的紧张性GABA能抑制。总的来说，我们的数据表明，一个模型显示，间隔释放的OXT和AVP差异影响侵略的女性通过调节LS子网络内的抑制音。在模式生物中，对雌性动物的攻击性研究不足。在这里，作者建立了一个模型，增强侵略性的处女雌性大鼠，并表明催产素和加压素系统差异调节侵略性的不同神经元群体的外侧隔的雌性大鼠。
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and arginine vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialysis approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), is required for aggression in female rats. Accordingly, increased activity of putative OXT receptor-positive neurons in the vLS, and decreased activity of putative AVP receptor-positive neurons in the dLS, are likely to underly aggression in female rats. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data suggest a model showing that septal release of OXT and AVP differentially affects aggression in females by modulating the inhibitory tone within LS sub-networks. Aggression in females is understudied in model organisms. Here, the authors establish a model of enhanced aggression in virgin female rats and show that oxytocin and vasopressin systems differentially modulate aggression in distinct neuronal populations of the lateral septum of female rats.
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影响因子：
25
作者：
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