Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation.
Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation.
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DOI：
10.3109/09553002.2011.583316
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发表时间：
2011-08
影响因子：
2.6
通讯作者：
Swartz HM
中科院分区：
文献类型：
--
作者：
Williams BB;Dong R;Nicolalde RJ;Matthews TP;Gladstone DJ;Demidenko E;Zaki BI;Salikhov IK;Lesniewski PN;Swartz HM
评估大规模袭击或事件后个人辐射暴露的能力已被认为是合理有效的紧急医疗响应的必要条件。牙釉质体内电子顺磁共振（EPR）光谱的开发就是为了满足这一需求。一种新型便携式 EPR 光谱仪是为了在紧急响应环境中促进牙齿剂量测定而开发的，用于测量模型系统中、未受辐射的受试者以及接受过 2 Gy 全身剂量的患者的上切牙。在模型系统中观察到线性剂量反应。与未受辐射的受试者相比，在受辐射的受试者中观察到辐射引起的 EPR 信号强度有统计学上的显着增加，剂量预测的估计标准误差为 0.9 + 0.3 Gy。这些结果表明，目前体内 EPR 牙齿剂量测定能够区分未受过辐射的受试者和接受过导致其面临急性辐射综合症风险的暴露的受试者。进一步提高剂量估算精度并确保紧急情况下可靠运行的程序和技术开发正在进行中。随着这些发展，EPR 牙齿剂量测定可能成为大量人群潜在辐射暴露后分类的宝贵资源。
The ability to estimate individual exposures to radiation following a large attack or incident has been identified as a necessity for rational and effective emergency medical response. In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need. A novel transportable EPR spectrometer, developed to facilitate tooth dosimetry in an emergency response setting, was used to measure upper incisors in a model system, in unirradiated subjects, and in patients who had received total body doses of 2 Gy. A linear dose response was observed in the model system. A statistically significant increase in the intensity of the radiation-induced EPR signal was observed in irradiated versus unirradiated subjects, with an estimated standard error of dose prediction of 0.9 + 0.3 Gy. These results demonstrate the current ability of in vivo EPR tooth dosimetry to distinguish between subjects who have not been irradiated and those who have received exposures that place them at risk for acute radiation syndrome. Procedural and technical developments to further increase the precision of dose estimation and ensure reliable operation in the emergency setting are underway. With these developments EPR tooth dosimetry is likely to be a valuable resource for triage following potential radiation exposure of a large population.
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影响因子：
2
作者：
Demidenko, E.;Williams, B. B.;Swartz, H. M.
通讯作者：
Swartz, H. M.
DOI：
10.1016/s0168-583x(01)00614-0
发表时间：
2001-09-01
影响因子：
1.3
作者：
Desrosiers, M;Schauer, DA
通讯作者：
Schauer, DA
影响因子：
2.2
作者：
Chen, Yuhchyau;Tsai, Ying;Dertinger, Stephen D.
通讯作者：
Dertinger, Stephen D.
影响因子：
2.2
作者：
Garty G;Chen Y;Salerno A;Turner H;Zhang J;Lyulko O;Bertucci A;Xu Y;Wang H;Simaan N;Randers-Pehrson G;Yao YL;Amundson SA;Brenner DJ
通讯作者：
Brenner DJ
影响因子：
2.2
作者：
Goans, RE;Holloway, EC;Ricks, RC
通讯作者：
Ricks, RC