Mechanisms for sweetness.

Mechanisms for sweetness.
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甜度的机制。

DOI:
10.3945/jn.111.149567
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发表时间:
2012-06
期刊:
The Journal of nutrition
影响因子:
--
通讯作者:
Molinary S
Molinary S
中科院分区:
其他
文献类型:
--
作者:
Fernstrom JD;Munger SD;Sclafani A;de Araujo IE;Roberts A;Molinary S

文献摘要

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过去十年中出现了大量有关甜味生理学的信息。本文回顾了这些数据,特别重点阐述了甜味受体、其在口腔味觉传导中的位置和作用、其在胃肠道中的非味觉功能(例如,在肠内分泌细胞中)以及参与甜味感觉处理的大脑回路。还考虑了使用啮齿动物来模拟人类甜味感知和反应的复杂性。此外,还针对这些问题讨论了与低热量甜味剂 (LCS) 相关的信息。特别考虑 LCS 对肠内分泌细胞功能的已知影响。
A remarkable amount of information has emerged in the past decade regarding sweet taste physiology. This article reviews these data, with a particular focus on the elucidation of the sweet taste receptor, its location and actions in taste transduction in the mouth, its nontaste functions in the gastrointestinal tract (e.g., in enteroendocrine cells), and the brain circuitry involved in the sensory processing of sweet taste. Complications in the use of rodents to model human sweet taste perception and responses are also considered. In addition, information relating to low-calorie sweeteners (LCS) is discussed in the context of these issues. Particular consideration is given to the known effects of LCS on enteroendocrine cell function.
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