Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis.
Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis.
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DOI：
10.1007/s00213-013-3369-1
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发表时间：
2014-04
影响因子：
3.4
通讯作者：
Miczek, Klaus A.
中科院分区：
文献类型：
--
作者：
Burke, Andrew R.;Miczek, Klaus A.
关键词：
过去十年中，关于青春期和药物滥用的研究大幅增加。然而，青春期压力经历后与药物成瘾相关的行为研究较少。我们专注于青少年压力对滥用药物交叉敏感性的啮齿动物模型。回顾青少年啮齿类动物的行为、多巴胺、促肾上腺皮质激素释放因子（CRF）和下丘脑垂体肾上腺（HPA）轴的个体发育。我们评估了青春期压力经历会导致对滥用药物过敏的证据，并提供了潜在的神经机制。许多证据表明，行为、多巴胺系统和 HPA 轴的最终成熟发生在青春期。在许多情况下，青春期的压力会增加苯丙胺和乙醇刺激的运动、偏好和自我给药。青少年压力对随后可卡因和尼古丁刺激的运动和偏好的影响尚不清楚。青少年压力的类型、压力和测试之间的时间间隔、物种、性别和测试的药物是成功交叉致敏程序的关键方法决定因素。中脑边缘多巴胺系统的敏化被认为是通过 CRF 调节对青少年和成人滥用药物的应激交叉敏化的基础。中皮质多巴胺水平降低似乎是青春期社会压力的独特后果。青春期压力可能通过 D2 多巴胺受体调节多巴胺合成或糖皮质激素促进皮质多巴胺纤维的修剪来减少皮质多巴胺的最终成熟。某些青少年逆境的啮齿动物模型可用于确定对滥用药物交叉敏感的神经机制。
Research on adolescence and drug abuse increased substantially in the past decade. However, drug-addiction related behaviors following stressful experiences during adolescence are less studied. We focus on rodent models of adolescent stress cross-sensitization to drugs of abuse. Review the ontogeny of behavior, dopamine, corticotropin-releasing factor (CRF), and the hypothalamic pituitary adrenal (HPA) axis in adolescent rodents. We evaluate evidence that stressful experiences during adolescence engender hypersensitivity to drugs of abuse and offer potential neural mechanisms. Much evidence suggests that final maturation of behavior, dopamine systems, and HPA axis occurs during adolescence. Stress during adolescence increases amphetamine- and ethanol-stimulated locomotion, preference, and self-administration under many conditions. The influence of adolescent stress on subsequent cocaine- and nicotine-stimulated locomotion and preference is less clear. The type of adolescent stress, temporal interval between stress and testing, species, sex, and the drug tested are key methodological determinants for successful cross-sensitization procedures. The sensitization of the mesolimbic dopamine system is proposed to underlie stress cross-sensitization to drugs of abuse in both adolescents and adults through modulation by CRF. Reduced levels of mesocortical dopamine appear to be a unique consequence of social stress during adolescence. Adolescent stress may reduce the final maturation of cortical dopamine through D2 dopamine receptor regulation of dopamine synthesis or glucocorticoid-facilitated pruning of cortical dopamine fibers. Certain rodent models of adolescent adversity are useful for determining neural mechanisms underlying the cross-sensitization to drugs of abuse.
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影响因子：
7.6
作者：
Andersen, SL;Teicher, MH
通讯作者：
Teicher, MH
影响因子：
3.6
作者：
BARDO, MT;BOWLING, SL;DWOSKIN, LP
通讯作者：
DWOSKIN, LP
影响因子：
4.7
作者：
Adriani, W;Laviola, G
通讯作者：
Laviola, G
影响因子：
1.7
作者：
Andersen, SL;Rutstein, M;Teicher, MH
通讯作者：
Teicher, MH
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL