Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls.
Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls.
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DOI：
10.1155/2018/3061974
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Wang P;Zhu Y;Xi S;Li S;Zhang Y
锰超氧化物歧化酶（MnSOD）在抵抗活性氧方面起着至关重要的作用。MnSOD Val16Ala多态性与癌症风险之间的关系已被广泛研究，但结果是矛盾的。为了获得更精确的相关性，我们对来自PubMed、Embase、中国知网（CNKI）和万方数据库的88项研究中的33098例病例和37831例对照进行了当前的meta分析。合并优势比（or）和95%置信区间（ci）用于评估关联强度。我们发现多态性与总体癌症风险增加相关（纯合子：OR = 1.09, 95% CI = 1.00-1.19；杂合子：OR = 1.07, 95% CI = 1.02-1.12；显性：OR = 1.08, 95% CI = 1.02-1.14；等位基因比较：OR = 1.06, 95% CI = 1.02-1.11）。分层分析进一步显示前列腺癌、亚洲人、高加索人、基于人群的研究、基于医院的研究、低质量和高质量研究的风险增加。然而，亚洲人MnSOD Val16Ala多态性增加的风险需要基于假阳性报告概率（FPRP）测试进一步验证。综上所述，本荟萃分析提示MnSOD Val16Ala多态性与癌症风险显著增加相关，这需要在单个大型研究中进一步验证。
Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species. The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory. To obtain more precision on the association, we performed the current meta-analysis with 33,098 cases and 37,831 controls from 88 studies retrieved from PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association. We found that the polymorphism was associated with an increased overall cancer risk (homozygous: OR = 1.09, 95% CI = 1.00–1.19; heterozygous: OR = 1.07, 95% CI = 1.02–1.12; dominant: OR = 1.08, 95% CI = 1.02–1.14; and allele comparison: OR = 1.06, 95% CI = 1.02–1.11). Stratification analysis further showed an increased risk for prostate cancer, Asians, Caucasians, population-based studies, hospital-based studies, low quality and high quality studies. However, the increased risk for MnSOD Val16Ala polymorphism among Asians needs further validation based on the false-positive report probability (FPRP) test. To summarize, this meta-analysis suggests that the MnSOD Val16Ala polymorphism is associated with significantly increased cancer risk, which needs further validation in single large studies.
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