Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis: Data from the Osteoarthritis Initiative (OAI).
Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis: Data from the Osteoarthritis Initiative (OAI).
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DOI：
10.1038/srep34202
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发表时间：
2016-09-27
影响因子：
4.6
通讯作者：
Eckstein F
中科院分区：
文献类型：
--
作者：
Wirth W;Maschek S;Roemer FW;Eckstein F
基于磁共振成像 (MRI) 的自旋-自旋弛豫时间 (T2) 绘图已被证明与软骨基质成分（水合作用、胶原蛋白含量和方向）相关。为了确定早期放射学膝骨关节炎 (ROA) 和 ROA 危险因素对股骨软骨成分的影响，我们研究了 60 名受试者（年龄 60.6±9.6 岁；BMI 27.8±4.8）的浅表和深层软骨 T2 层的基线值和一年变化，其中一名膝盖有明确的骨赘（早期 ROA， n = 32），对侧膝关节有 ROA 危险因素（riskROA，n = 28），以及 89 名健康受试者（年龄 55.0 ± 7.5 岁；BMI 24.4 ± 3.1），无 ROA 体征或危险因素。早期ROA和风险ROA膝盖之间的基线T2在浅层（48.0±±3.5ms vs 48.1±3.1ms）或深层（37.3±±2.5ms vs 37.3±1.8ms）没有显着差异。然而，健康膝关节的浅层 T2 (45.4±2.3ms) 显着低于早期 ROA 或风险 ROA 膝关节 (p≤≤0.001)，深层 T2 (35.8±1.8ms) 显着低于风险 ROA 膝关节 (p=0.006)。仅在健康膝盖中检测到 T2 的显着纵向变化（浅表：0.5±1.4 毫秒；深部：0.8±1.3 毫秒）。这些结果并不表明早期 ROA（骨赘）与软骨成分存在关联（通过 T2 映射评估），而观察到有和没有 ROA 危险因素的膝盖之间的软骨成分有所不同。
Magnetic resonance imaging (MRI)-based spin-spin relaxation time (T2) mapping has been shown to be associated with cartilage matrix composition (hydration, collagen content & orientation). To determine the impact of early radiographic knee osteoarthritis (ROA) and ROA risk factors on femorotibial cartilage composition, we studied baseline values and one-year change in superficial and deep cartilage T2 layers in 60 subjects (age 60.6 ± 9.6 y; BMI 27.8 ± 4.8) with definite osteophytes in one knee (earlyROA, n = 32) and with ROA risk factors in the contralateral knee (riskROA, n = 28), and 89 healthy subjects (age 55.0 ± 7.5 y; BMI 24.4 ± 3.1) without signs or risk factors of ROA. Baseline T2 did not differ significantly between earlyROA and riskROA knees in the superficial (48.0 ± 3.5 ms vs. 48.1 ± 3.1 ms) or the deep layer (37.3 ± 2.5 ms vs. 37.3 ± 1.8 ms). However, healthy knees showed significantly lower superficial layer T2 (45.4 ± 2.3 ms) than earlyROA or riskROA knees (p ≤ 0.001) and significantly lower deep layer T2 (35.8 ± 1.8 ms) than riskROA knees (p = 0.006). Significant longitudinal change in T2 (superficial: 0.5 ± 1.4 ms; deep: 0.8 ± 1.3 ms) was only detected in healthy knees. These results do not suggest an association of early ROA (osteophytes) with cartilage composition, as assessed by T2 mapping, whereas cartilage composition was observed to differ between knees with and without ROA risk factors.
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影响因子：
7
作者：
Baum, T.;Joseph, G. B.;Karampinos, D. C.;Jungmann, P. M.;Link, T. M.;Bauer, J. S.
通讯作者：
Bauer, J. S.
影响因子：
4.4
作者：
Jungmann, Pia M.;Kraus, Mareen S.;Nardo, Lorenzo;Liebl, Hans;Alizai, Hamza;Joseph, Gabby B.;Liu, Felix;Lynch, John;McCulloch, Chuck E.;Nevitt, Michael C.;Link, Thomas M.
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Link, Thomas M.
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作者：
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通讯作者：
Nessaiver M
影响因子：
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作者：
Mosher, TJ;Liu, Y;Smith, MB
通讯作者：
Smith, MB
影响因子：
4.7
作者：
Cotofana, Sebastian;Buck, Robert;Eckstein, Felix
通讯作者：
Eckstein, Felix