Comparing mouse and human cingulate cortex organization using functional connectivity
Comparing mouse and human cingulate cortex organization using functional connectivity
复制标题
使用功能连接比较小鼠和人类扣带皮层组织
DOI：
10.1101/2023.09.04.556193
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Van Hout A
中科院分区：
文献类型：
--
作者：
Van Hout A
人类大脑的扩展扣带皮层的细分与许多高级行为有关，并受到一系列神经精神疾病的影响。它的解剖结构，功能和对治疗的反应经常使用非人类动物（包括小鼠）进行研究。然而，人类和小鼠额叶皮层的相似性，包括扣带区，仍然没有完全理解。一些解释强调小鼠扣带皮层和人类扣带皮层之间的相似性，而另一些则强调与人类颗粒前额叶皮层的相似性。我们使用比较神经成像研究小鼠和人类扣带皮层的连接性，允许小鼠“金标准”示踪剂和成像数据之间的比较，此外，小鼠和人类之间的比较使用可比的成像数据。我们发现物种之间的扣带组织的总体相似性，包括前扣带和中扣带区和压后区。然而，人类的扣带回包含了比老鼠更细粒度的组织，它与老鼠不存在的前额区有联系。诸如此类的结果有助于正式解决物种间的大脑组织，并旨在改善从临床前到人类结果的转化。
The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However, the similarity of human and mouse frontal cortex, including cingulate areas, is still not fully understood. Some accounts emphasize resemblances between mouse cingulate cortex and human cingulate cortex while others emphasize similarities with human granular prefrontal cortex. We use comparative neuroimaging to study the connectivity of the cingulate cortex in the mouse and human, allowing comparisons between mouse ‘gold standard’ tracer and imaging data, and, in addition, comparison between the mouse and the human using comparable imaging data. We find overall similarities in organization of the cingulate between species, including anterior and midcingulate areas and a retrosplenial area. However, human cingulate contains subareas with a more fine-grained organization than is apparent in the mouse and it has connections to prefrontal areas not present in the mouse. Results such as these help formally address between-species brain organization and aim to improve the translation from preclinical to human results.
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影响因子：
25
作者：
Grandjean, Joanes;Desrosiers-Gregoire, Gabriel;Anckaerts, Cynthia;Angeles-Valdez, Diego;Ayad, Fadi;Barriere, David A.;Blockx, Ines;Bortel, Aleksandra;Broadwater, Margaret;Cardoso, Beatriz M.;Celestine, Marina;Chavez-Negrete, Jorge E.;Choi, Sangcheon;Christiaen, Emma;Clavijo, Perrin;Colon-Perez, Luis;Cramer, Samuel;Daniele, Tolomeo;Dempsey, Elaine;Diao, Yujian;Doelemeyer, Arno;Dopfel, David;Dvorakova, Lenka;Falfan-Melgoza, Claudia;Fernandes, Francisca F.;Fowler, Caitlin F.;Fuentes-Ibanez, Antonio;Garin, Clement;Gelderman, Eveline;Golden, Carla E. M.;Guo, Chao C. G.;Henckens, Marloes J. A. G.;Hennessy, Lauren A.;Herman, Peter;Hofwijks, Nita;Horien, Corey;Ionescu, Tudor M.;Jones, Jolyon;Kaesser, Johannes;Kim, Eugene;Lambers, Henriette;Lazari, Alberto;Lee, Sung-Ho;Lillywhite, Amanda;Liu, Yikang;Liu, Yanyan Y.;Lopez-Castro, Alejandra;Lopez-Gil, Xavier;Ma, Zilu;MacNicol, Eilidh;Madularu, Dan;Mandino, Francesca;Marciano, Sabina;McAuslan, Matthew J.;McCunn, Patrick;McIntosh, Alison;Meng, Xianzong;Meyer-Baese, Lisa;Missault, Stephan;Moro, Federico;Naessens, Daphne M. P.;Nava-Gomez, Laura J.;Nonaka, Hiroi;Ortiz, Juan J.;Paasonen, Jaakko;Peeters, Lore M.;Pereira, Mickael;Perez, Pablo D.;Pompilus, Marjory;Prior, Malcolm;Rakhmatullin, Rustam;Reimann, Henning M.;Reinwald, Jonathan;Del Rio, Rodrigo Triana;Rivera-Olvera, Alejandro;Ruiz-Perez, Daniel;Russo, Gabriele;Rutten, Tobias J.;Ryoke, Rie;Sack, Markus;Salvan, Piergiorgio;Sanganahalli, Basavaraju G.;Schroeter, Aileen;Seewoo, Bhedita J.;Selingue, Erwan;Seuwen, Aline;Shi, Bowen;Sirmpilatze, Nikoloz;Smith, Joanna A.;Smith, Corrie;Sobczak, Filip;Stenroos, Petteri J.;Straathof, Milou;Strobelt, Sandra;Sumiyoshi, Akira;Takahashi, Kengo;Torres-Garcia, Maria E.;Tudela, Raul;van den Berg, Monica;van der Marel, Kajo;van Hout, Aran T. B.;Vertullo, Roberta;Vidal, Benjamin;Vrooman, Roel M.;Wang, Victora X.;Wank, Isabel;Watson, David J. G.;Yin, Ting;Zhang, Yongzhi;Zurbruegg, Stefan;Achard, Sophie;Alcauter, Sarael;Auer, Dorothee P.;Barbier, Emmanuel L.;Baudewig, Juergen;Beckmann, Christian F.;Beckmann, Nicolau;Becq, Guillaume J. P. C.;Blezer, Erwin L. A.;Bolbos, Radu;Boretius, Susann;Bouvard, Sandrine;Budinger, Eike;Buxbaum, Joseph D.;Cash, Diana;Chapman, Victoria;Chuang, Kai-Hsiang;Ciobanu, Luisa;Coolen, Bram F.;Dalley, Jeffrey W.;Dhenain, Marc;Dijkhuizen, Rick M.;Esteban, Oscar;Faber, Cornelius;Febo, Marcelo;Feindel, Kirk W.;Forloni, Gianluigi;Fouquet, Jeremie;Garza-Villarreal, Eduardo A.;Gass, Natalia;Glennon, Jeffrey C.;Gozzi, Alessandro;Grohn, Olli;Harkin, Andrew;Heerschap, Arend;Helluy, Xavier;Herfert, Kristina;Heuser, Arnd;Homberg, Judith R.;Houwing, Danielle J.;Hyder, Fahmeed;Ielacqua, Giovanna Diletta;Jelescu, Ileana O.;Johansen-Berg, Heidi;Kaneko, Gen;Kawashima, Ryuta;Keilholz, Shella D.;Keliris, Georgios A.;Kelly, Clare;Kerskens, Christian;Khokhar, Jibran Y.;Kind, Peter C.;Langlois, Jean-Baptiste;Lerch, Jason P.;Lopez-Hidalgo, Monica A.;Manahan-Vaughan, Denise;Marchand, Fabien;Mars, Rogier B.;Marsella, Gerardo;Micotti, Edoardo;Munoz-Moreno, Emma;Near, Jamie;Niendorf, Thoralf;Otte, Willem M.;Pais-Roldan, Patricia;Pan, Wen-Ju;Prado-Alcala, Roberto A.;Quirarte, Gina L.;Rodger, Jennifer;Rosenow, Tim;Sampaio-Baptista, Cassandra;Sartorius, Alexander;Sawiak, Stephen J.;Scheenen, Tom W. J.;Shemesh, Noam;Shih, Yen-Yu Ian;Shmuel, Amir;Soria, Guadalupe;Stoop, Ron;Thompson, Garth J.;Till, Sally M.;Todd, Nick;van der Linden, Annemie;van der Toorn, Annette;van Tilborg, Geralda A. F.;Vanhove, Christian;Veltien, Andor;Verhoye, Marleen;Wachsmuth, Lydia;Weber-Fahr, Wolfgang;Wenk, Patricia;Yu, Xin;Zerbi, Valerio;Zhang, Nanyin;Zhang, Baogui B.;Zimmer, Luc;Devenyi, Gabriel A.;Chakravarty, M. Mallar;Hess, Andreas
通讯作者：
Hess, Andreas
影响因子：
5.7
作者：
Van Essen, David C.;Smith, Stephen M.;Barch, Deanna M.;Behrens, Timothy E. J.;Yacoub, Essa;Ugurbil, Kamil
通讯作者：
Ugurbil, Kamil
生物学模型系统：历史、哲学和实际问题
影响因子：
0.6
作者：
P. King
通讯作者：
P. King
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.0905314106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Margulies, Daniel S.;Vincent, Justin L.;Petrides, Michael
通讯作者：
Petrides, Michael