Fat metabolism links germline stem cells and longevity in C. elegans.
Fat metabolism links germline stem cells and longevity in C. elegans.
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DOI：
10.1126/science.1162011
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发表时间：
2008-11-07
期刊：
影响因子：
--
通讯作者：
Ruvkun G
中科院分区：
文献类型：
--
作者：
Wang MC;O'Rourke EJ;Ruvkun G
脂肪代谢、生殖和衰老是相互交织的调节轴;然而，它们耦合的机制仍然知之甚少。我们发现，生殖干细胞（GSC）积极调节秀丽隐杆线虫的脂质水解，这反过来又调节寿命。GSC停滞通过诱导特异性脂肪脂肪酶促进全身性脂解。随后，促进脂肪动员，延长寿命。这种脂肪酶在脂肪储存组织中的组成型表达产生瘦的和长寿的动物。这种脂肪酶是由胰岛素信号传导减少诱导的脂质水解和延长寿命的关键因素。这些结果表明C.脂肪代谢和长寿。
Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.
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