Neural correlates of anxiety sensitivity during masked presentation of affective faces.
Neural correlates of anxiety sensitivity during masked presentation of affective faces.
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DOI：
10.1002/da.20788
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发表时间：
2011-03
影响因子：
7.4
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
--
作者：
Killgore, William D. S.;Britton, Jennifer C.;Price, Lauren M.;Gold, Andrea L.;Deckersbach, Thilo;Rauch, Scott L.
焦虑敏感性（AS），害怕与焦虑体验相关的想法，症状和社会后果的倾向，与发展焦虑症的风险增加有关。一些证据表明，焦虑敏感性指数（ASI），AS结构的测量，较高的分数与激活前岛叶皮层在公开的情绪感知。虽然ASI提供了测量AS的身体、精神失能和社会关注的子量表分数，但没有研究探讨这些因素与情感处理过程中区域大脑激活之间的关系。我们假设，对恐惧相关刺激的孤立反应主要与ASI的身体关注子量表有关，特别是对于特定恐惧症的受试者样本。成人健康对照（HC; n=22）和个体与特定的恐惧症，小动物亚型（SAP; n=17），完成了ASI，并进行了功能性磁共振成像（fMRI），同时从事一个向后掩蔽的情感知觉任务，提出情绪面部刺激低于有意识的感知阈值。两组在ASI、状态或特质焦虑评分或焦虑激活方面没有差异。对于合并样本以及HC和SAP组，总ASI评分与右侧中/前额叶激活呈正相关。多元回归分析显示，AS和岛叶激活之间的关系主要是由物理问题只占。研究结果支持假设的作用，右前额叶在内脏/interoceptive方面的焦虑敏感性，即使在掩蔽的情感刺激。
Anxiety Sensitivity (AS), the tendency to fear the thoughts, symptoms, and social consequences associated with the experience of anxiety, is associated with increased risk for developing anxiety disorders. Some evidence suggests that higher scores on the Anxiety Sensitivity Index (ASI), a measure of the AS construct, are associated with activation of the anterior insular cortex during overt emotion perception. Although the ASI provides subscale scores measuring Physical, Mental Incapacitation, and Social Concerns of AS, no study has examined the relationship between these factors and regional brain activation during affect processing. We hypothesized that insular responses to fear-related stimuli would be primarily related to the Physical Concerns subscale of the ASI, particularly for a sample of subjects with specific phobias. Adult healthy controls (HC; n=22) and individuals with specific phobia, small animal subtype (SAP; n=17), completed the ASI and underwent functional magnetic resonance imaging (fMRI) while engaged in a backward-masked affect perception task that presents emotional facial stimuli below the threshold of conscious perception. Groups did not differ in ASI, state or trait anxiety scores, or insula activation. Total ASI scores were positively correlated with activation in the right middle/anterior insula for the combined sample and for the HC and SAP groups separately. Multiple regression analysis revealed that the relationship between AS and insular activation was primarily accounted for by Physical Concerns only. Findings support the hypothesized role of the right anterior insula in the visceral/interoceptive aspects of anxiety sensitivity, even in response to masked affective stimuli.
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影响因子：
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