Ontogeny and neural substrates of the context preexposure facilitation effect.
Ontogeny and neural substrates of the context preexposure facilitation effect.
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DOI：
10.1016/j.nlm.2010.11.011
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发表时间：
2011-02
影响因子：
2.7
通讯作者：
Stanton, Mark E.
中科院分区：
文献类型：
--
作者：
Schiffino, Felipe L.;Murawski, Nathen J.;Rosen, Jeffrey B.;Stanton, Mark E.
背景性恐惧条件反射在大鼠出生后第23天左右出现。这被认为反映了依赖于校园的联合学习，它将上下文的各个特征绑定到一个统一的表示中。然而，上下文条件也可以通过独立于校园的、基于特征的简单关联来支持，这些可以在PD 23 -24中操作。为了解决这个问题，我们研究了个体发育的一个变体的上下文恐惧条件反射，称为上下文预暴露促进效应（CPFE），其中暴露于上下文和（立即）脚休克发生在连续的场合。这种变体需要合取，而不是基于特征的简单关联。我们测试了PD 17、24和31大鼠的CPFE与传统背景条件反射（Exp. 1)以及具有更强增强的CPFE（Exp. 2）的情况。CPFE出现在PD 24，无论干扰强度如何，并与背景条件反射平行。在PD 24预暴露前，将NMDA拮抗剂MK-801注入背侧海马，消除了CPFE，而在预暴露后进行的注入没有影响（Exp. 3）。这些研究结果表明，早在PD 24的CPFE海马NMDA受体的作用，并牵连在个体发育的上下文恐惧条件的连接学习机制。
Contextual fear conditioning emerges around post-natal day (PD) 23 in the rat. This is thought to reflect hippocampus-dependent conjunctive learning, which binds the individual features of the context into a unified representation. However, context conditioning can also be supported by hippocampus-independent, feature-based simple associations and these may operate at PD23–24. To address this issue, we studied the ontogeny of a variant of contextual fear conditioning, termed the context-preexposure-facilitation-effect (CPFE), in which exposure to context and (immediate) foot shock occur on successive occasions. This variant requires conjunctive as opposed to feature-based simple associations. We tested PD17, 24, and 31 rats on the CPFE vs. conventional context conditioning (Exp. 1) and on the CPFE with stronger reinforcement (Exp. 2). The CPFE emerged on PD24 regardless of reinforcer strength and in parallel with context conditioning. Infusions of the NMDA antagonist, MK-801, into the dorsal hippocampus just before preexposure on PD24 eliminated the CPFE, whereas infusions occurring after preexposure had no effect (Exp. 3). These findings demonstrate a role of hippocampal NMDA receptors in the CPFE as early as PD24 and implicate conjunctive learning mechanisms in the ontogeny of contextual fear conditioning.
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影响因子：
2.7
作者：
Brasser, SM;Spear, NE
通讯作者：
Spear, NE
DOI：
10.1037/0097-7403.19.2.121
发表时间：
1993-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
FANSELOW, MS;DECOLA, JP;YOUNG, SL
通讯作者：
YOUNG, SL
影响因子：
1.9
作者：
Burman, M. A.;Murawski, N. J.;Schiffino, F. L.;Rosen, J. B.;Stanton, M. E.
通讯作者：
Stanton, M. E.
影响因子：
56.9
作者：
Langston, Rosamund F.;Ainge, James A.;Moser, May-Britt
通讯作者：
Moser, May-Britt
影响因子：
56.9
作者：
KIM, JJ;FANSELOW, MS
通讯作者：
FANSELOW, MS