Effects of ozone and other pollutants on the pulmonary function of adult hikers.
Effects of ozone and other pollutants on the pulmonary function of adult hikers.
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DOI：
10.1289/ehp.9810693
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发表时间：
1998-02
影响因子：
10.4
通讯作者：
Speizer FE
中科院分区：
文献类型：
--
作者：
Korrick SA;Neas LM;Dockery DW;Gold DR;Allen GA;Hill LB;Kimball KD;Rosner BA;Speizer FE
本研究评估了环境臭氧（O3）、细颗粒物（PM2.5）和强气溶胶酸性对运动成人肺功能的急性影响。在1991年和1992年的夏天，志愿者（18-64岁）被要求从山的徒步旅行者。华盛顿，新罕布什尔州。有完整协变量的非吸烟志愿者（n = 530）在远足前后测量肺功能。我们计算了每个徒步旅行者的1秒用力呼气量（FEV 1）、用力肺活量（FVC）、两者的比值（FEV 1/FVC）、用力呼气流量占FVC的25 - 75%（FEF 25 -75%）和峰值呼气流速（PEFR）的变化百分比。平均O3暴露范围为21至74 ppb。在调整了年龄，性别，吸烟状况（以前与从未）、哮喘或喘息史、增加时间、环境温度和其他协变量，FEV 1下降2.6%[95%置信区间（CI），0.4-4.7; p = 0.02]和2.2% FVC下降（CI，0.8-3.5; p =0.003）。两种FVC均存在一致的下降相关性（下降0.4%; CI，0.2 -0.6，p = 0.001）和PEFR（下降0.8%; CI，0.01-1.6; p = 0.05）与PM2.5和PEFR的下降（下降0.4%; CI，0.1-0.7; p = 0.02），在这些暴露的四分位数范围内具有强气溶胶酸性。有哮喘或喘息史的徒步旅行者（n = 40）对臭氧的反应性比其他人高四倍。长期户外运动，低水平暴露于O3，PM2.5和强酸性气溶胶与成人肺功能的显着影响。有哮喘或喘鸣病史的徒步旅行者有明显更大的空气污染相关的肺功能变化。
This study evaluated the acute effects of ambient ozone (O3), fine particulate matter (PM2.5), and strong aerosol acidity on the pulmonary function of exercising adults. During the summers of 1991 and 1992, volunteers (18-64 years of age) were solicited from hikers on Mt. Washington, New Hampshire. Volunteer nonsmokers with complete covariates (n = 530) had pulmonary function measured before and after their hikes. We calculated each hiker's posthike percentage change in forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), the ratio of these two (FEV1/FVC), forced expiratory flow between 25 and 75% of FVC(FEF25-75%), and peak expiratory flow rate (PEFR). Average O3 exposures ranged from 21 to 74 ppb. After adjustment for age,sex, smoking status (former versus never), history of asthma or wheeze, hours hiked, ambient temperature, and other covariates, there was a 2.6% decline in FEV1 [95% confidence interval (CI), 0.4-4.7; p = 0.02] and a 2.2% decline in FVC (CI, 0.8-3.5; p =0.003) for each 50 ppb increment in mean O3. There were consistent associations of decrements in both FVC (0.4% decline; CI,0.2-0.6, p = 0.001) and PEFR (0.8% decline; CI, 0.01-1.6; p = 0.05) with PM2.5 and of decrements in PEFR (0.4% decline; CI, 0.1-0.7; p = 0.02) with strong aerosol acidity across the interquartile range of these exposures. Hikers with asthma or a history of wheeze (n = 40) had fourfold greater responsiveness to ozone than others. With prolonged outdoor exercise, low-level exposures to O3, PM2.5, and strong aerosol acidity were associated with significant effects on pulmonary function among adults. Hikers with a history of asthma or wheeze had significantly greater air pollution-related changes in pulmonary function.
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影响因子：
20.8
作者：
DOCKERY, DW;POPE, CA
通讯作者：
POPE, CA
影响因子：
4.4
作者：
ANEJA, VP;LI, Z
通讯作者：
LI, Z
DOI：
10.1080/08940630.1988.10466349
发表时间：
1988-01-01
期刊：
JAPCA-THE INTERNATIONAL JOURNAL OF AIR POLLUTION CONTROL AND HAZARDOUS WASTE MANAGEMENT
影响因子：
--
作者：
FOLINSBEE, LJ;MCDONNELL, WF;HORSTMAN, DH
通讯作者：
HORSTMAN, DH
DOI：
10.1164/ajrccm/147.4.818
发表时间：
1993-04-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
MCDONNELL, WF;MULLER, KE;SHY, CM
通讯作者：
SHY, CM
DOI：
10.1080/00022470.1984.10465814
发表时间：
1984-01-01
期刊：
JOURNAL OF THE AIR POLLUTION CONTROL ASSOCIATION
影响因子：
--
作者：
AVOL, EL;LINN, WS;HACKNEY, JD
通讯作者：
HACKNEY, JD