Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
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DOI：
10.1371/journal.pone.0092358
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hennige AM
中科院分区：
文献类型：
--
作者：
Sartorius T;Peter A;Schulz N;Drescher A;Bergheim I;Machann J;Schick F;Siegel-Axel D;Schürmann A;Weigert C;Häring HU;Hennige AM
肉桂对糖尿病患者的治疗显示出血糖浓度和胰岛素敏感性的改善，但其潜在机制尚不清楚。这项工作旨在通过分离星形胶质细胞和肥胖和糖尿病小鼠模型来阐明肉桂效应对大脑的影响。将肉桂成分(丁香酚、肉桂醛)加入到星形胶质细胞和肝细胞中，以测量胰岛素信号和糖原合成。给OB/ob小鼠补充玉桂提取物6周，观察其大脑皮层活动、运动和能量消耗情况。测定脑组织和肝脏组织中胰岛素的作用。丁香酚处理原代星形胶质细胞可促进糖原合成，而肉桂醛的作用减弱。在体内脑功能方面，肉桂提取物改善了ob/ob小鼠的胰岛素敏感性和脑活动，并改善了胰岛素刺激的运动活动。此外，由于肉桂提取物，ob/ob小鼠的空腹血糖水平和葡萄糖耐量显著改善，而胰岛素分泌没有改变。这与降低甘油三酯、增加肝糖原含量和改善肝脏组织中的胰岛素作用相对应。在体外，暴露于肉桂的粮农组织细胞没有表现出胰岛素作用的变化。总之，肉桂提取物改善了胰岛素在大脑中的作用，以及大脑的活动和运动。这一特殊作用可能代表了肉桂改善脑内胰岛素作用的一个重要中心特征，并介导了外周代谢变化，以降低肝脏脂肪和改善血糖动态平衡。
Treatment of diabetic subjects with cinnamon demonstrated an improvement in blood glucose concentrations and insulin sensitivity but the underlying mechanisms remained unclear. This work intends to elucidate the impact of cinnamon effects on the brain by using isolated astrocytes, and an obese and diabetic mouse model. Cinnamon components (eugenol, cinnamaldehyde) were added to astrocytes and liver cells to measure insulin signaling and glycogen synthesis. Ob/ob mice were supplemented with extract from cinnamomum zeylanicum for 6 weeks and cortical brain activity, locomotion and energy expenditure were evaluated. Insulin action was determined in brain and liver tissues. Treatment of primary astrocytes with eugenol promoted glycogen synthesis, whereas the effect of cinnamaldehyde was attenuated. In terms of brain function in vivo, cinnamon extract improved insulin sensitivity and brain activity in ob/ob mice, and the insulin-stimulated locomotor activity was improved. In addition, fasting blood glucose levels and glucose tolerance were greatly improved in ob/ob mice due to cinnamon extracts, while insulin secretion was unaltered. This corresponded with lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues. In vitro, Fao cells exposed to cinnamon exhibited no change in insulin action. Together, cinnamon extract improved insulin action in the brain as well as brain activity and locomotion. This specific effect may represent an important central feature of cinnamon in improving insulin action in the brain, and mediates metabolic alterations in the periphery to decrease liver fat and improve glucose homeostasis.
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DOI：
10.1007/978-1-60327-029-8_10
发表时间：
2010
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Nagababu, Enika;Rifkind, Joseph M.;Boindala, Sesikeran;Nakka, Lakshmaiah
通讯作者：
Nakka, Lakshmaiah
影响因子：
4.2
作者：
Choi, IY;Seaquist, ER;Gruetter, R
通讯作者：
Gruetter, R
影响因子：
6.1
作者：
Chericoni, S;Prieto, JA;Morelli, I
通讯作者：
Morelli, I
影响因子：
9.8
作者：
Couturier, Karine;Qin, Bolin;Anderson, Richard A.
通讯作者：
Anderson, Richard A.
影响因子：
4.4
作者：
Machann, J;Thamer, C;Schick, F
通讯作者：
Schick, F