Stress reduces conception probabilities across the fertile window: evidence in support of relaxation.
Stress reduces conception probabilities across the fertile window: evidence in support of relaxation.
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DOI：
10.1016/j.fertnstert.2010.06.078
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发表时间：
2011-06
影响因子：
6.7
通讯作者：
Pyper, Cecilia
中科院分区：
文献类型：
--
作者：
Louis, Germaine M. Buck;Lum, Kirsten J.;Sundaram, Rajeshwari;Chen, Zhen;Kim, Sungduk;Lynch, Courtney D.;Schisterman, Enrique F.;Pyper, Cecilia
评估唾液应激生物标志物（皮质醇和α-淀粉酶）和雌性生殖力。前瞻性队列设计。英国.对274名年龄在18-40岁之间试图怀孕的妇女进行了随访，直到怀孕或六个月经周期。妇女在每个周期的第6天收集基础唾液样本，并使用生育监测仪识别排卵和妊娠检测试剂盒进行妊娠检测。暴露量包括唾液皮质醇（μg/dL）和α-淀粉酶（U/mL）浓度。分别通过离散时间生存和贝叶斯建模技术估计的受孕时间和受孕窗口期间的受孕概率来测量生育力。α-淀粉酶而不是皮质醇浓度与第一周期的生育力呈负相关（生育力比值比= 0.85; 95%置信区间0.67，1.09），调整夫妇的年龄，性交频率，饮酒量。与唾液α-淀粉酶浓度处于下四分位数的女性相比，唾液α-淀粉酶浓度处于上四分位数的女性在第一个周期尝试怀孕期间的受孕概率显著降低（HPD-0.284; 95%区间-0.540，-0.029）。压力显着降低受孕的可能性，每天在受精窗口，可能通过交感神经通路发挥其作用。
To assess salivary stress biomarkers (cortisol and alpha-amylase) and female fecundity. Prospective cohort design. United Kingdom. 274 women aged 18–40 years attempting pregnancy were followed until pregnant or for six menstrual cycles. Women collected basal saliva samples on day 6 of each cycle, and used fertility monitors to identify ovulation and pregnancy test kits for pregnancy detection. Exposures included salivary cortisol (μg/dL) and alpha-amylase (U/mL) concentrations. Fecundity was measured by time-to-pregnancy and the probability of pregnancy during the fertile window as estimated from discrete-time survival and Bayesian modeling techniques, respectively. Alpha-amylase but not cortisol concentrations were negatively associated with fecundity in the first cycle (fecundity odds ratio = 0.85; 95% confidence interval 0.67, 1.09) after adjusting for couples’ ages, intercourse frequency, and alcohol consumption. Significant reductions in the probability of conception across the fertile window during the first cycle attempting pregnancy were observed for women whose salivary concentrations of alpha-amylase were in the upper quartiles in comparison to women in the lower quartiles (HPD −0.284; 95% interval −0.540, −0.029). Stress significantly reduced the probability of conception each day during the fertile window, possibly exerting its effect through the sympathetic medullar pathway.
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