Occurrence of depression and anxiety prior to Parkinson's disease.
Occurrence of depression and anxiety prior to Parkinson's disease.
复制标题
DOI：
10.1016/j.parkreldis.2010.06.014
复制
发表时间：
2010-11
影响因子：
4.1
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Jacob EL;Gatto NM;Thompson A;Bordelon Y;Ritz B
探讨抑郁、焦虑与帕金森病的关系。许多患有PD的人在运动症状发作之前患有抑郁和焦虑。研究表明，这些精神疾病可能是PD或前驱非运动症状的危险因素。我们在加州的三个县采用基于人群的方法，招募了371例PD病例，402例人群和115例同胞对照。我们记录了终生抑郁/焦虑诊断和精神药物使用的自我报告。我们调整了年龄，种族，性别，吸烟包年和教育，并在排除（滞后）索引/诊断日期的2年，5年，10年和20年内首次发生的诊断和药物使用后进行分析。病例更有可能在索引日期前的任何时间接受抑郁或焦虑诊断（OR 1.42，95% CI 1.01，2.00），但不太可能同时接受诊断和治疗（OR 1.11，95% CI 0.77，1.60）。在PD诊断后5年内，男性PD患者接受诊断联合治疗的频率高于人群对照（OR 2.21，95% CI 1.21，4.04; 2年滞后：OR 2.44，95% CI 1.29，4.61; 5年滞后：OR 1.67，95% CI 0.80，3.49）。我们没有看到女性的任何差异。与同胞对照相比，病例的结果与人群对照的结果相似。这些结果表明，抑郁和焦虑可能是PD前驱期的早期症状。
To assess the relationship between depression and anxiety and Parkinson’s disease (PD). Many people with PD suffer from depression and anxiety prior to the onset of motor symptoms. Studies suggest these psychiatric conditions may be risk factors for PD or prodromal non-motor symptoms. Using a population-based approach in three California counties, we recruited 371 incident PD cases, 402 population and 115 sibling controls. We recorded self-reports of lifetime depression/anxiety diagnoses and use of psychotropic medications. We adjusted for age, race, sex, pack-years of smoking, and education, and also conducted analyses after excluding (lagging) both diagnoses and medication use first occurring within 2, 5, 10, and 20 years of the index/diagnosis date. Cases were more likely to have received a diagnosis of depression or anxiety at any time prior to index date (OR 1.42, 95% CI 1.01, 2.00), but were not more likely to have been both diagnosed and treated (OR 1.11, 95% CI 0.77, 1.60). Male PD patients received diagnoses combined with treatment more often than population controls within 5 years of PD diagnosis (OR 2.21, 95% CI 1.21, 4.04; 2 year lag: OR 2.44, 95% CI 1.29, 4.61; 5 year lag: OR 1.67, 95% CI 0.80, 3.49). We did not see any differences for females. Results for cases compared to sibling controls were similar to those for population controls. These results suggest that depression and anxiety may be early symptoms during the prodromal phase of PD.
登录
查看更多内容
影响因子：
8.6
作者：
Gonera, EG;vantHof, M;Horstink, WIM
通讯作者：
Horstink, WIM
影响因子：
14.5
作者：
TAYLOR, AE;SAINTCYR, JA;KENNY, FT
通讯作者：
KENNY, FT
影响因子：
8.6
作者：
Leentjens, AFG;Van den Akker, M;Verhey, FRJ
通讯作者：
Verhey, FRJ
影响因子：
4.4
作者：
Schrag, Anette
通讯作者：
Schrag, Anette
影响因子：
8.6
作者：
Kang, GA;Bronstein, JM;Ritz, B
通讯作者：
Ritz, B