Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age.
Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age.
复制标题
DOI：
10.1111/j.1474-9726.2008.00409.x
复制
发表时间：
2008-10
期刊：
影响因子：
7.8
通讯作者：
Tilly JL
中科院分区：
文献类型：
--
作者：
Selesniemi K;Lee HJ;Tilly JL
女性与年龄相关的卵巢功能衰竭预示着进入绝经后生活的转变，其特点是生育能力丧失以及心血管疾病、骨质疏松症和认知功能障碍的风险增加。不幸的是，没有任何方法可以延缓人类卵巢功能随着年龄的增长而丧失。啮齿动物研究表明，热量限制（CR）可以延长雌性的生育寿命；然而，这项工作大部分在断奶时启动 CR，导致青少年生长发育迟缓和性成熟延迟。在此，我们在小鼠中测试了成年期开始的 CR 是否可以延缓生殖衰老。 CR 4 个月后，与随意 (AL) 喂养的年龄匹配对照相比，卵巢卵泡储备增加了一倍，在交配试验中，其在 15.5 个月大时表现出生育能力丧失。 CR 雌性在 15.5 个月大时恢复 AL 喂养，大约一半的雌性在另外 6 个月内保持生育能力，三分之一的雌性在 23 个月大时继续生育后代。值得注意的是，与老年的 AL 喂养对照相比，先 CR 再喂养 AL 的雌性的繁殖力和产后后代的存活率显着提高。例如，在 10 至 23 个月大的时期，由 AL 喂养的雌性产下的 54 个后代中，只有 22% 存活。相比之下，15.5至23个月大的CR然后AL喂养的小鼠产下94只幼崽，其中超过73%存活下来，没有任何明显的并发症。这些数据表明，在小鼠中，成年发病的 CR 可以将雌性生殖轴的功能维持到高龄，并显着提高老年雌性所生后代的产后存活率。
Age-related ovarian failure in women heralds the transition into postmenopausal life, which is characterized by a loss of fertility and increased risk for cardiovascular disease, osteoporosis and cognitive dysfunction. Unfortunately, there are no options available for delaying loss of ovarian function with age in humans. Rodent studies have shown that caloric restriction (CR) can extend female fertile lifespan; however, much of this work initiated CR at weaning, which causes stunted adolescent growth and a delayed onset of sexual maturation. Herein we tested in mice if CR initiated in adulthood could delay reproductive aging. After 4 months of CR, the ovarian follicle reserve was doubled compared to ad libitum (AL)-fed age-matched controls, which in mating trials exhibited a loss of fertility by 15.5 months of age. In CR females returned to AL feeding at 15.5 months of age, approximately one-half remained fertile for 6 additional months and one-third continued to deliver offspring through 23 months of age. Notably, fecundity of CR-then-AL-fed females and postnatal offspring survival rates were dramatically improved compared with aging AL-fed controls. For example, between 10 and 23 months of age, only 22% of the 54 offspring delivered by AL-fed females survived. In contrast, over 73% of the 94 pups delivered by 15.5- to 23-month-old CR-then-AL-fed mice survived without any overt complications. These data indicate that in mice adult-onset CR maintains function of the female reproductive axis into advanced age and dramatically improves postnatal survival of offspring delivered by aged females.
登录
查看更多内容
影响因子：
6.1
作者：
Charleston, Jay S.;Hansen, Karl R.;Klein, Nancy A.
通讯作者：
Klein, Nancy A.
影响因子：
--
作者：
BALL, ZB;BARNES, RH;VISSCHER, MB
通讯作者：
VISSCHER, MB
DOI：
10.1196/annals.1297.074
发表时间：
2004-01-01
期刊：
STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE
影响因子：
--
作者：
Ingram, DK;Anson, RM;Roth, GS
通讯作者：
Roth, GS
影响因子：
64.8
作者：
Johnson, J;Canning, J;Tilly, JL
通讯作者：
Tilly, JL
DOI：
10.1530/jrf.0.0570253
发表时间：
1979-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
MERRY, BJ;HOLEHAN, AM
通讯作者：
HOLEHAN, AM