Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains: A Systematic Review and Meta-analysis.
Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains: A Systematic Review and Meta-analysis.
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DOI：
10.1001/jamanetworkopen.2022.28008
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发表时间：
2022-08-01
影响因子：
13.8
通讯作者：
中科院分区：
文献类型：
--
作者：
由不同的SARS-CoV-2毒株引起的COVID-19潜伏期有多长？在对141篇文章进行的系统综述和荟萃分析中，合并的潜伏期为6.57天。由α、β、δ和Omicron变体引起的COVID-19的潜伏期分别为5.00、4.50、4.41和3.42天。这些结果表明，随着突变株的进化，COVID-19的潜伏期从Alpha变异株到Omicron变异株逐渐缩短。本系统性综述和荟萃分析估计了由SARS-CoV-2的各种菌株引起的COVID-19的潜伏期。进行了几项研究来估计COVID-19的平均潜伏期;然而，不同SARS-CoV-2变异体引起的COVID-19的潜伏期并没有得到很好的描述。系统评估COVID-19的潜伏期以及已发表研究中不同SARS-CoV-2变异株引起的COVID-19潜伏期。检索了2019年12月1日至2022年2月10日期间的PubMed、EMBASE和ScienceDirect。对COVID-19潜伏期的原始研究，定义为从感染到出现体征和症状的时间。根据系统性综述和荟萃分析的首选报告项目（PRISMA）报告指南，3名审评员于2022年3月独立提取了合格研究的数据。这些参数，或足够的信息，以促进这些值的计算，来自随机效应荟萃分析。潜伏期和不同SARS-CoV-2毒株的平均估计值。共纳入142项研究，8112例患者。合并孵育期为6.57天（95% CI，6.26-6.88），范围为1.80 - 18.87天。分别在1项研究（6374例患者）、1项研究（10例患者）、6项研究（2368例患者）和5项研究（829例患者）中报告了α、β、δ和Omicron变体引起的COVID-19潜伏期。COVID-19的平均潜伏期为5.00天（95% CI，4.94-5.06天）对于α变体引起的病例，4.50天β变体为4.41天（95% CI，1.83-7.17天），Delta变体为4.41天（95% CI，3.76-5.05天），Omicron变体为3.42天（95% CI，2.88-3.96天）。平均潜伏期为7.43天（95% CI，5.75-9.11天）（即年龄在60岁以上），8.82天（95% CI，8.19-9.45天）（18岁或以下），非重症患者为6.99天（95% CI，6.07-7.92天），重症患者为6.69天（95% CI，4.53-8.85天）。这项研究的结果表明，SARS-CoV-2在整个COVID-19大流行期间不断进化和突变，产生了具有不同增强传播力和毒力的变体。确定不同变种的潜伏期是确定隔离期的关键因素。
What are the incubation periods of COVID-19 caused by different SARS-CoV-2 strains? In this systematic review and meta-analysis of 141 articles, the pooled incubation period was 6.57 days. The incubation periods of COVID-19 caused by the Alpha, Beta, Delta, and Omicron variants were 5.00, 4.50, 4.41, and 3.42 days, respectively. These results suggest that with the evolution of mutant strains, the incubation period of COVID-19 decreased gradually from Alpha variant to Omicron variant. This systematic review and meta-analysis estimates the incubation periods of COVID-19 caused by various strains of SARS-CoV-2. Several studies were conducted to estimate the average incubation period of COVID-19; however, the incubation period of COVID-19 caused by different SARS-CoV-2 variants is not well described. To systematically assess the incubation period of COVID-19 and the incubation periods of COVID-19 caused by different SARS-CoV-2 variants in published studies. PubMed, EMBASE, and ScienceDirect were searched between December 1, 2019, and February 10, 2022. Original studies of the incubation period of COVID-19, defined as the time from infection to the onset of signs and symptoms. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, 3 reviewers independently extracted the data from the eligible studies in March 2022. The parameters, or sufficient information to facilitate calculation of those values, were derived from random-effects meta-analysis. The mean estimate of the incubation period and different SARS-CoV-2 strains. A total of 142 studies with 8112 patients were included. The pooled incubation period was 6.57 days (95% CI, 6.26-6.88) and ranged from 1.80 to 18.87 days. The incubation period of COVID-19 caused by the Alpha, Beta, Delta, and Omicron variants were reported in 1 study (with 6374 patients), 1 study (10 patients), 6 studies (2368 patients) and 5 studies (829 patients), respectively. The mean incubation period of COVID-19 was 5.00 days (95% CI, 4.94-5.06 days) for cases caused by the Alpha variant, 4.50 days (95% CI, 1.83-7.17 days) for the Beta variant, 4.41 days (95% CI, 3.76-5.05 days) for the Delta variant, and 3.42 days (95% CI, 2.88-3.96 days) for the Omicron variant. The mean incubation was 7.43 days (95% CI, 5.75-9.11 days) among older patients (ie, aged over 60 years old), 8.82 days (95% CI, 8.19-9.45 days) among infected children (ages 18 years or younger), 6.99 days (95% CI, 6.07-7.92 days) among patients with nonsevere illness, and 6.69 days (95% CI, 4.53-8.85 days) among patients with severe illness. The findings of this study suggest that SARS-CoV-2 has evolved and mutated continuously throughout the COVID-19 pandemic, producing variants with different enhanced transmission and virulence. Identifying the incubation period of different variants is a key factor in determining the isolation period.
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