Diverse and active roles for adipocytes during mammary gland growth and function.
Diverse and active roles for adipocytes during mammary gland growth and function.
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DOI：
10.1007/s10911-010-9187-8
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发表时间：
2010-09
影响因子：
2.5
通讯作者：
Aimo, Lucila
中科院分区：
文献类型：
--
作者：
Hovey, Russell C.;Aimo, Lucila
乳腺的独特之处在于其需要与通常被称为乳房脂肪垫的脂肪组织仓库密切相关地发育。正如本期所讨论的，乳腺脂肪垫代表了一个复杂的基质微环境，包括各种细胞类型。在这篇文章中，我们集中在脂肪细胞作为局部调节上皮细胞的生长及其功能在哺乳期。这种讨论引起了几个重要的考虑。在乳腺脂肪垫内的不同基质组织类型及其脂肪细胞之间存在明确而密切的相互关系。此外，这些关系都是阶段和物种依赖，虽然许多问题仍然没有答案，关于他们在这些不同的状态中的作用。一些证据还表明，乳腺脂肪垫内的脂肪细胞可能与其他脂肪库中的脂肪细胞功能不同。最后，过去和未来的技术提供了各种机会来模拟这些复杂性，以便更精确地描绘乳腺内脂肪细胞的许多潜在功能。彻底了解这种细胞类型在乳腺中的作用可以提供许多机会来改变乳腺癌风险和泌乳性能。
The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and their function during lactation. Several important considerations arise from such a discussion. There is a clear and close interrelationship between different stromal tissue types within the mammary fat pad and its adipocytes. Furthermore, these relationships are both stage- and species-dependent, although many questions remain unanswered regarding their roles in these different states. Several lines of evidence also suggest that adipocytes within the mammary fat pad may function differently from those in other fat depots. Finally, past and future technologies present a variety of opportunities to model these complexities in order to more precisely delineate the many potential functions of adipocytes within the mammary glands. A thorough understanding of the role for this cell type in the mammary glands could present numerous opportunities to modify both breast cancer risk and lactation performance.
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影响因子：
--
作者：
ANBAZHAGAN, R;BARTEK, J;GUSTERSON, BA
通讯作者：
GUSTERSON, BA
影响因子：
2.5
作者：
Couldrey, C;Moitra, J;Green, J
通讯作者：
Green, J
DOI：
10.1016/j.jsbmb.2009.03.010
发表时间：
2009-07-01
影响因子：
4.1
作者：
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通讯作者：
Boon, Wah Chin
影响因子：
6.2
作者：
BLAIR, PHYLLIS B.;MORETTI, R. L.
通讯作者：
MORETTI, R. L.
影响因子：
4
作者：
Berry, SDK;Howard, RD;Akers, RM
通讯作者：
Akers, RM