Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death.
Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death.
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DOI：
10.1186/1471-2407-12-625
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发表时间：
2012-12-28
期刊：
影响因子：
3.8
通讯作者：
Boccardo F
中科院分区：
文献类型：
--
作者：
Nuzzo PV;Rubagotti A;Zinoli L;Ricci F;Salvi S;Boccardo S;Boccardo F
本研究的目的是评估前列腺术后POSTN表达的预后价值。应用免疫反应记分法(IRS)检测90例前列腺癌(PCa)组织和正常组织中Periostin(POSTN)的表达。采用t检验比较癌标本与正常标本的IRS值。采用Pearson‘s检验分析POSTN表达与临床病理特征的关系。用Kaplan-Meier法构建PSA无进展曲线和生存曲线，并用对数等级检验进行比较。采用COX技术建立多参数模型，单因素分析后将所有预测PSA进展或死亡的协变量加入模型中。间质和上皮性POSTN在肿瘤组织中的表达均显著增加。特别是，我们发现，与正常组织相比，前列腺癌间质的表达显著高于上皮性表达(p<；0.000和p=0.001)。虽然高间质表达与较短的生存期显著相关(p=0.008.0 1)，但低上皮评分与较短的无PSA生存期显著相关(p=0.0 4)，这表明POSTN在生物学上扮演着明显相反的角色，取决于其所涉及的机制。虽然需要通过更大规模的研究进一步验证，但我们的研究结果表明，POSTN可能是一种新的PCa预后标志物。
The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy. Periostin (POSTN) expression in prostate cancer (PCa) and in normal specimens was evaluated in 90 patients by an immuno-reactive score(IRS) based on the intensity of immunostaining and on the quantity of stained cells. The t-test was applied to compare IRS values in cancer specimens to values in normal specimens. Pearson’s test was used to correlate POSTN expression to clinical pathologic features. PSA progression-free and survival curves were constructed by the Kaplan–Meier method and compared using the log-rank test. Multi-parametric models were constructed according to the Cox technique adding all the covariates predicting for either PSA progression or death into the models after univariate analysis. Both stromal and epithelial POSTN expression were significantly increased in tumor tissues. In particular, we found stromal expression to be significantly higher than epithelial expression as compared to normal tissues (p<0.000 and p=0.001).A significant correlation between POSTN epithelial expression and extra-prostatic extension was found (p=0.03). While high stromal expression was significantly associated with shorter survival (p=0.008), a low epithelial score significantly correlated with shorter PSA-free survival (p=0.04), suggesting that POSTN plays an apparently opposing biological role depending on its compartmentalization.Regardless of the mechanism that is involved, patients showing both high stromal and low epithelial expression made up a subgroup with a very bleak prognosis. Although requiring further validation through larger studies, our findings show that POSTN might represent a novel prognostic marker for PCa.
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影响因子：
8.8
作者：
Peto, R;Pike, M C;Armitage, P;Breslow, N E;Cox, D R;Howard, S V;Mantel, N;McPherson, K;Peto, J;Smith, P G
通讯作者：
Smith, P G
影响因子：
3.8
作者：
Tischler V;Fritzsche FR;Wild PJ;Stephan C;Seifert HH;Riener MO;Hermanns T;Mortezavi A;Gerhardt J;Schraml P;Jung K;Moch H;Soltermann A;Kristiansen G
通讯作者：
Kristiansen G
影响因子：
8.8
作者：
Peto R;Pike MC;Armitage P;Breslow NE;Cox DR;Howard SV;Mantel N;McPherson K;Peto J;Smith PG
通讯作者：
Smith PG
影响因子：
3.5
作者：
Morra, Laura;Moch, Holger
通讯作者：
Moch, Holger
影响因子：
4.5
作者：
Montironi, R;Mazzuccheli, R;Algaba, F
通讯作者：
Algaba, F