Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma.
Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma.
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DOI：
10.1007/s10552-012-9967-0
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发表时间：
2012-07
影响因子：
2.3
通讯作者：
Cerhan, James R.
中科院分区：
文献类型：
--
作者：
Kelly, Jennifer L.;Drake, Matthew T.;Fredericksen, Zachary S.;Asmann, Yan W.;Liebow, Mark;Shanafelt, Tait D.;Feldman, Andrew L.;Ansell, Stephen M.;Macon, William R.;Herr, Megan M.;Wang, Alice H.;Nowakowski, Grzegorz S.;Call, Timothy G.;Habermann, Thomas M.;Slager, Susan L.;Witzig, Thomas E.;Cerhan, James R.
据推测，维生素D介导的阳光照射和非霍奇金淋巴瘤（NHL）的风险在最近的几项研究报告之间的反比关系。我们评估了年龄<13岁、13-21岁、22-40岁和41岁以上的自我报告的阳光暴露和来自4个与维生素D代谢相关的候选基因（RXR、VDR、CYP 24 A1、CYP 27 B1）的19个单核苷酸多态性（SNP）与NHL风险的相关性。该分析包括1，009例新诊断的NHL病例和1，233例来自正在进行的临床研究的频率匹配对照。采用非条件logistic回归估计比值比（OR）、95%置信区间（CI）和趋势检验。在13-21岁时，随着阳光照射的增加，NHL风险显著降低（OR≥15 vs. ≤3 h/周= 0.68; 95% CI，0.43-1.08; ptrend = 0.0025），暴露时年龄越大，风险越低。我们观察到VDR中的3个SNP和CYP 24 A1：rs 886441中的1个SNP的显著主效应关联（OR每等位基因= 0.82; 95% CI，0.70-0.96; p = 0.016），rs3819545（OR每等位基因= 1.24; 95% CI，1.10-1.40; p = 0.00043），和rs 2239186 VDR（OR每等位基因= 1.22; 95% CI，1.05-1.41; p = 0.0095）和CYP 24 A1 rs 2762939（OR每等位基因= 0.85; 95% CI，0.75-0.98; p = 0.023）。此外，年龄13-21岁时的阳光照射对NHL总体风险的影响似乎受到VDR生殖系变异的影响（rs 4516035; pinteraction = 0.0066）。探索性分析表明，这些协会NHL亚型的潜在异质性。这些结果表明，VDR的生殖系遗传变异，因此维生素D途径，可能介导早期生活阳光照射和NHL风险之间的关联。
It has been hypothesized that vitamin D mediates the inverse relationship between sun exposure and non-Hodgkin lymphoma (NHL) risk reported in several recent studies. We evaluated the association of self-reported sun exposure at ages <13, 13–21, 22–40, and 41+ years and 19 single nucleotide polymorphisms (SNPs) from 4 candidate genes relevant to vitamin D metabolism (RXR, VDR, CYP24A1, CYP27B1) with NHL risk. This analysis included 1,009 newly diagnosed NHL cases and 1,233 frequency-matched controls from an ongoing clinic-based study. Odds ratios (OR), 95 % confidence intervals (CI), and tests for trend were estimated using unconditional logistic regression. There was a significant decrease in NHL risk with increased sun exposure at ages 13–21 years (OR≥15 vs. ≤3 h/week = 0.68; 95 % CI, 0.43–1.08; ptrend = 0.0025), which attenuated for older ages at exposure. We observed significant main effect associations for 3 SNPs in VDR and 1 SNP in CYP24A1: rs886441 (ORper-allele = 0.82; 95 % CI, 0.70–0.96; p = 0.016), rs3819545 (ORper-allele = 1.24; 95 % CI, 1.10–1.40; p = 0.00043), and rs2239186 (ORper-allele = 1.22; 95 % CI, 1.05–1.41; p = 0.0095) for VDR and rs2762939 (ORper-allele = 0.85; 95 % CI, 0.75–0.98; p = 0.023) for CYP24A1. Moreover, the effect of sun exposure at age 13–21 years on overall NHL risk appears to be modified by germline variation in VDR (rs4516035; pinteraction = 0.0066). Exploratory analysis indicated potential heterogeneity of these associations by NHL subtype. These results suggest that germline genetic variation in VDR, and therefore the vitamin D pathway, may mediate an association between early life sun exposure and NHL risk.
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DOI：
10.1016/j.jphotobiol.2010.08.001
发表时间：
2010-12-02
影响因子：
5.4
作者：
Freedman, D. Michal;Kimlin, Michael G.;Hoffbeck, Richard W.;Alexander, Bruce H.;Linet, Martha S.
通讯作者：
Linet, Martha S.
影响因子：
20.3
作者：
Chang, Ellen T.;Canchola, Alison J.;Horn-Ross, Pamela L.
通讯作者：
Horn-Ross, Pamela L.
影响因子：
5
作者：
Chang, Ellen T.;Balter, Katarina M.;Adami, Hans-Olov
通讯作者：
Adami, Hans-Olov
影响因子：
2.4
作者：
Kelly JL;Friedberg JW;Calvi LM;van Wijngaarden E;Fisher SG
通讯作者：
Fisher SG
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth