Neural Signaling of Cortisol, Childhood Emotional Abuse, and Depression-Related Memory Bias.
Neural Signaling of Cortisol, Childhood Emotional Abuse, and Depression-Related Memory Bias.
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DOI：
10.1016/j.bpsc.2017.11.005
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Birn RM
中科院分区：
文献类型：
--
作者：
Abercrombie HC;Frost CP;Walsh EC;Hoks RM;Cornejo MD;Sampe MC;Gaffey AE;Plante DT;Ladd CO;Birn RM
皮质醇对学习和神经可塑性有很强的影响，但对抑郁症中负性记忆偏差的影响知之甚少。动物模型显示，厌恶性的呕吐改变了糖皮质激素（主要是啮齿动物的皮质酮;灵长类动物的皮质醇）对成年后学习和神经可塑性的影响。我们调查了是否有童年情绪虐待史（EA）调节了皮质醇给药（CORT）与安慰剂对抑郁症患者情绪记忆形成的影响。参与者包括75名未经药物治疗的妇女，她们有不同程度的抑郁严重程度和/或EA病史。在一项双盲交叉研究中，我们使用fMRI来测量CORT（与安慰剂相比）对情绪记忆形成过程中神经功能的影响。CORT消除了众所周知的抑郁症严重程度和负性记忆偏差之间的关系，这一发现可以用EA严重程度来解释。对于有严重EA病史的女性，CORT减少了抑郁相关的负性记忆偏差，并使愉快刺激的回忆正常化。EA的严重程度也缓和CORT对神经功能的影响：在妇女的历史严重EA，CORT增加激活补充运动区（SMA）在不愉快的相对愉快的图片。此外，SMA激活预测在CORT期间编码的图片的负偏置减少。这些结果表明，增加皮质醇信号可能是有益的神经认知抑郁症的妇女虐待的历史。这一发现证实了先前的研究，即存在或不存在不良情绪在抑郁症中具有重要的病因学意义。这些发现表明了针对皮质醇信号传导的治疗方法的潜在神经认知机制，这在治疗情感障碍方面显示出了希望。
Cortisol has potent effects on learning and neuroplasticity, but little is known about its effects on negative memory biases in depression. Animal models show that aversive caregiving alters effects of glucocorticoids (primarily corticosterone in rodents; cortisol in primates) on learning and neuroplasticity into adulthood. We investigated whether history of childhood emotional abuse (EA) moderated effects of cortisol administration (CORT) vs. placebo on emotional memory formation in depression. Participants included 75 unmedicated women with varying levels of depression severity and/or EA history. In a double-blind crossover investigation, we used fMRI to measure effects of CORT (vs. Placebo) on neural function during emotional memory formation. CORT eliminated the well-known relation between depression severity and negative memory bias, a finding explained by EA severity. For women with history of severe EA, CORT reduced depression-related negative memory bias and normalized recall for pleasant stimuli. EA severity also moderated CORT’s effects on neural function: in women with history of severe EA, CORT increased activation in supplementary motor area (SMA) during unpleasant relative to pleasant pictures. Additionally, SMA activation predicted reduced negative bias for pictures encoded during CORT. These results suggest that increasing cortisol signaling may be neurocognitively beneficial in depressed women with history of maltreatment. The findings corroborate prior research suggesting that presence or absence of adverse caregiving is etiologically important in depression. The findings suggest potential neurocognitive mechanisms of therapeutics targeting cortisol signaling, which show promise in treating affective disorders.
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影响因子：
4.8
作者：
Abercrombie HC;Jahn AL;Davidson RJ;Kern S;Kirschbaum C;Halverson J
通讯作者：
Halverson J
影响因子：
3.5
作者：
Drury SS;Sánchez MM;Gonzalez A
通讯作者：
Gonzalez A
影响因子：
5.3
作者：
Cattaneo A;Macchi F;Plazzotta G;Veronica B;Bocchio-Chiavetto L;Riva MA;Pariante CM
通讯作者：
Pariante CM
DOI：
10.1073/pnas.1605044113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Dum, Richard P.;Levinthal, David J.;Strick, Peter L.
通讯作者：
Strick, Peter L.
童年虐待史、消极认知方式和成年后抑郁发作
影响因子：
2.8
作者：
Gibb, BE;Alloy, LB;Tierney, S
通讯作者：
Tierney, S