Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis.
Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis.
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膳食补充剂和益生菌在调节微生物群和骨骼健康中的作用：肠骨轴。
DOI：
10.3390/cells11040743
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发表时间：
2022-02-21
期刊：
影响因子：
6
通讯作者：
Wahli W
中科院分区：
文献类型：
--
作者：
de Sire A;de Sire R;Curci C;Castiglione F;Wahli W
骨质疏松症的特征是骨微结构改变，骨密度降低，导致脆性骨折的发生率。约有2亿人受到骨质疏松症的影响，这是全球主要的健康负担。骨质疏松症的发病机制涉及多种因素。今天，肠道内环境平衡的改变正在被研究为降低骨骼健康的潜在额外危险因素，因此，作为一种新的潜在治疗靶点。肠道微生物区系通过调节血清IGF-1水平影响破骨细胞的活动，同时也影响肠道对钙的吸收。因此，肠道生物失调影响骨骼健康也就不足为奇了。微生物区系改变影响破骨细胞中的OPG/RANKL途径，并与骨强度和骨质量降低相关。在这种情况下，人们假设膳食补充剂、益生元和益生菌有助于肠道微生态平衡，这对骨骼健康很重要。本综述的目的是描述膳食补充剂和益生菌作为骨健康调节和骨质疏松症的治疗剂，通过肠道微生物区系调节的最新进展。
Osteoporosis is characterized by an alteration of bone microstructure with a decreased bone mineral density, leading to the incidence of fragility fractures. Around 200 million people are affected by osteoporosis, representing a major health burden worldwide. Several factors are involved in the pathogenesis of osteoporosis. Today, altered intestinal homeostasis is being investigated as a potential additional risk factor for reduced bone health and, therefore, as a novel potential therapeutic target. The intestinal microflora influences osteoclasts’ activity by regulating the serum levels of IGF-1, while also acting on the intestinal absorption of calcium. It is therefore not surprising that gut dysbiosis impacts bone health. Microbiota alterations affect the OPG/RANKL pathway in osteoclasts, and are correlated with reduced bone strength and quality. In this context, it has been hypothesized that dietary supplements, prebiotics, and probiotics contribute to the intestinal microecological balance that is important for bone health. The aim of the present comprehensive review is to describe the state of the art on the role of dietary supplements and probiotics as therapeutic agents for bone health regulation and osteoporosis, through gut microbiota modulation.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
3.7
作者：
Beukhof CM;Medici M;van den Beld AW;Hollenbach B;Hoeg A;Visser WE;de Herder WW;Visser TJ;Schomburg L;Peeters RP
通讯作者：
Peeters RP
影响因子：
2.5
作者：
Castaneda M;Smith KM;Nixon JC;Hernandez CJ;Rowan S
通讯作者：
Rowan S
影响因子：
5.6
作者：
Britton, Robert A.;Irwin, Regina;Quach, Darin;Schaefer, Laura;Zhang, Jing;Lee, Taehyung;Parameswaran, Narayanan;McCabe, Laura R.
通讯作者：
McCabe, Laura R.
影响因子：
4.5
作者：
Bornet, FRJ;Brouns, F;Duvillier, V
通讯作者：
Duvillier, V