Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.
复制标题
活性氧生成系统应对光动力癌症治疗的挑战
DOI：
10.1039/c6cs00271d
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发表时间：
2016-11-21
影响因子：
46.2
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Zhou Z;Song J;Nie L;Chen X
活性氧（ROS）介导的机制是影响光动力疗法（PDT）疗效的主要原因。PDT过程是基于光、光敏剂（PS）和氧之间的级联协同效应，这极大地有利于治疗的时空控制。该过程还在不同水平引起了几个未解决的挑战，包括（i）光的有限穿透深度限制了传统PDT仅用于浅表肿瘤;（ii）氧依赖剥夺了缺氧肿瘤的PDT治疗;（iii）由于同时产生热，光可能使光疗结果复杂化;（iv）将PS特异性递送到亚细胞细胞器以发挥有效毒性仍然是一个问题;以及（v）传统PS的不期望的白光活化和自催化的副作用。纳米技术和纳米医学的最新进展为通过光动力或非光动力程序开发ROS生成系统提供了新的机会，同时应对当前PDT方法的挑战。本文综述了活性氧的研究现状，并探讨了其在肿瘤治疗中的应用前景。我们希望这篇综述能促进ROS介导的肿瘤治疗的临床前研究和临床实践。
Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
29.4
作者：
Chan, Emory M.;Levy, Elizabeth S.;Cohen, Bruce E.
通讯作者：
Cohen, Bruce E.
影响因子：
14
作者：
Chen, Cheng-Lung;Kuo, Ling-Ru;Chen, Yang-Yuan
通讯作者：
Chen, Yang-Yuan
能够使用 980 nm 激光产生单线态氧的均匀亚 50 nm 磁性/上转换荧光双峰成像剂
影响因子：
4.3
作者：
Chen, Feng;Zhang, Shengjian;Shi, Jianlin
通讯作者：
Shi, Jianlin
影响因子：
3.9
作者：
Ahmad, Moiz;Pratx, Guillem;Xing, Lei
通讯作者：
Xing, Lei