Ancient gene transfer from algae to animals: mechanisms and evolutionary significance.
Ancient gene transfer from algae to animals: mechanisms and evolutionary significance.
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从藻类到动物的古代基因转移：机制和进化意义
DOI：
10.1186/1471-2148-12-83
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发表时间：
2012-06-12
影响因子：
3.4
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Ni T;Yue J;Sun G;Zou Y;Wen J;Huang J
背景水平基因转移（HGT）传统上被认为在动物等多细胞真核生物中很少见。最近，在领鞭毛虫中发现了许多源自其他藻类的基因。考虑到领鞭毛虫是动物现存的近亲，我们推测远古HGT可能发生在动物的单细胞祖先中，并影响了动物的长期进化。结果通过基因组筛选、系统发育和结构域分析，我们在被囊动物中鉴定出14个基因家族，包括92个基因，这些基因很可能来源于杂项光合作用。 真核生物。几乎所有这些基因家族都分布在不同的动物中，这表明它们大多是由动物的共同祖先获得的。它们的多种起源也表明这些基因并非源自特定的藻类内共生体。此外，我们分析中发现的大多数基因在功能上与分子运输、细胞调节和甲基化信号传导相关，这表明这些基因的获得可能促进了祖先动物的细胞间通讯。 结论我们的研究结果提供了额外的证据，表明质体真核生物中的藻类基因并不完全来源于历史质体，因此对于解释真核生物的进化很重要 光合作用。最重要的是，我们的数据首次证明动物体内可能存在更古老获得的基因，并且古代 HGT 事件在动物进化中发挥了重要作用。
BackgroundHorizontal gene transfer (HGT) is traditionally considered to be rare in multicellular eukaryotes such as animals. Recently, many genes of miscellaneous algal origins were discovered in choanoflagellates. Considering that choanoflagellates are the existing closest relatives of animals, we speculated that ancient HGT might have occurred in the unicellular ancestor of animals and affected the long-term evolution of animals.ResultsThrough genome screening, phylogenetic and domain analyses, we identified 14 gene families, including 92 genes, in the tunicateCiona intestinalisthat are likely derived from miscellaneous photosynthetic eukaryotes. Almost all of these gene families are distributed in diverse animals, suggesting that they were mostly acquired by the common ancestor of animals. Their miscellaneous origins also suggest that these genes are not derived from a particular algal endosymbiont. In addition, most genes identified in our analyses are functionally related to molecule transport, cellular regulation and methylation signaling, suggesting that the acquisition of these genes might have facilitated the intercellular communication in the ancestral animal.ConclusionsOur findings provide additional evidence that algal genes in aplastidic eukaryotes are not exclusively derived from historical plastids and thus important for interpreting the evolution of eukaryotic photosynthesis. Most importantly, our data represent the first evidence that more anciently acquired genes might exist in animals and that ancient HGT events have played an important role in animal evolution.
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影响因子：
9.2
作者：
Hackett, JD;Yoon, HS;Bhattacharya, D
通讯作者：
Bhattacharya, D
影响因子：
56.9
作者：
Armbrust, EV;Berges, JA;Rokhsar, DS
通讯作者：
Rokhsar, DS
影响因子：
56.9
作者：
Hotopp, Julie C. Dunning;Clark, Michael E.;Werren, John H.
通讯作者：
Werren, John H.
DOI：
10.1073/pnas.0335769100
发表时间：
2003-02-04
影响因子：
11.1
作者：
Hannaert, V;Saavedra, E;Opperdoes, FR
通讯作者：
Opperdoes, FR
影响因子：
12.3
作者：
Hooper SD;Berg OG
通讯作者：
Berg OG