Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612 fish eaters, 18,298 vegetarians, and 2246 vegans.
Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612 fish eaters, 18,298 vegetarians, and 2246 vegans.
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DOI：
10.3945/ajcn.113.071266
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Travis RC
中科院分区：
文献类型：
--
作者：
Key TJ;Appleby PN;Crowe FL;Bradbury KE;Schmidt JA;Travis RC
背景：素食饮食可能会影响癌症的风险。目的：目的是描述英国大样本素食者和非素食者的癌症发病率。设计图：这是对两项前瞻性研究的汇总分析，包括61，647名英国男性和女性，其中包括32，491名肉食者，8612名鱼类食用者和20，544名素食者（包括2246名素食者）。癌症发病率通过全国癌症登记处进行跟踪。采用多变量考克斯比例风险模型估计素食者的癌症风险。结果如下：经过平均14.9年的随访，有4998例癌症事件：3275例肉食者（10.1%），520例鱼类食用者（6.0%），1203例素食者（5.9%）。以下癌症的风险在饮食组之间存在显著异质性：胃癌[与肉食者相比，RR（95%CI）：0.62（0.27，1.43），在鱼类和0.37（0.19，0.69）素食者; P-异质性= 0.006]，结直肠癌[RR（95% CI）：0.66（0.48，0.92），在鱼类和1.03（0.84，1.26）素食者; P-异质性= 0.033]，淋巴和造血组织癌[RR（95% CI）：0.96（0.70，1.32），0.64（0.49，0.84）素食者; P-异质性= 0.005]，多发性骨髓瘤[RR（95% CI）：0.77（0.34，1.76），0.23（0.09，0.59）素食者; P-异质性= 0.010]，所有研究中心合并[RR（95% CI）：0.88（0.80，0.97）在鱼类食用者和0.88（0.82，0.95）在素食者; P-异质性= 0.0007]。结论：在英国人群中，吃鱼和素食者患某些癌症的风险低于肉食者。
Background: Vegetarian diets might affect the risk of cancer. Objective: The objective was to describe cancer incidence in vegetarians and nonvegetarians in a large sample in the United Kingdom. Design: This was a pooled analysis of 2 prospective studies including 61,647 British men and women comprising 32,491 meat eaters, 8612 fish eaters, and 20,544 vegetarians (including 2246 vegans). Cancer incidence was followed through nationwide cancer registries. Cancer risk by vegetarian status was estimated by using multivariate Cox proportional hazards models. Results: After an average follow-up of 14.9 y, there were 4998 incident cancers: 3275 in meat eaters (10.1%), 520 in fish eaters (6.0%), and 1203 in vegetarians (5.9%). There was significant heterogeneity between dietary groups in risks of the following cancers: stomach cancer [RRs (95% CIs) compared with meat eaters: 0.62 (0.27, 1.43) in fish eaters and 0.37 (0.19, 0.69) in vegetarians; P-heterogeneity = 0.006], colorectal cancer [RRs (95% CIs): 0.66 (0.48, 0.92) in fish eaters and 1.03 (0.84, 1.26) in vegetarians; P-heterogeneity = 0.033], cancers of the lymphatic and hematopoietic tissue [RRs (95% CIs): 0.96 (0.70, 1.32) in fish eaters and 0.64 (0.49, 0.84) in vegetarians; P-heterogeneity = 0.005], multiple myeloma [RRs (95% CIs): 0.77 (0.34, 1.76) in fish eaters and 0.23 (0.09, 0.59) in vegetarians; P-heterogeneity = 0.010], and all sites combined [RRs (95% CIs): 0.88 (0.80, 0.97) in fish eaters and 0.88 (0.82, 0.95) in vegetarians; P-heterogeneity = 0.0007]. Conclusion: In this British population, the risk of some cancers is lower in fish eaters and vegetarians than in meat eaters.
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影响因子：
7.1
作者：
Appleby, PN;Thorogood, M;Key, TJA
通讯作者：
Key, TJA
影响因子：
7.1
作者：
Key, Timothy J.;Appleby, Paul N.;Allen, Naomi E.
通讯作者：
Allen, Naomi E.
影响因子：
3.7
作者：
Chan DS;Lau R;Aune D;Vieira R;Greenwood DC;Kampman E;Norat T
通讯作者：
Norat T
DOI：
10.1016/j.bpg.2006.04.008
发表时间：
2006-01-01
影响因子：
3.2
作者：
Forman, D.;Burley, V. J.
通讯作者：
Burley, V. J.
影响因子：
105.7
作者：
THOROGOOD, M;MANN, J;MCPHERSON, K
通讯作者：
MCPHERSON, K