Coordinated, multi-joint, fatigue-resistant feline stance produced with intrafascicular hind limb nerve stimulation.
Coordinated, multi-joint, fatigue-resistant feline stance produced with intrafascicular hind limb nerve stimulation.
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DOI：
10.1088/1741-2560/9/2/026019
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发表时间：
2012-04
影响因子：
4
通讯作者：
Clark GA
中科院分区：
文献类型：
--
作者：
Normann RA;Dowden BR;Frankel MA;Wilder AM;Hiatt SD;Ledbetter NM;Warren DA;Clark GA
优美的骨骼运动需要在多个关节周围产生扭矩的多个肌肉的协调激活。本文所描述的工作集中在一个这样的运动，站姿，这需要协调激活臀部，膝盖和踝关节周围的伸肌。外部刺激在这些肌肉中引起的力都与肌肉长度和缩短速度有复杂的依赖关系，其中一些肌肉是双关节的。为了重现麻醉猫的坐立动作，我们使用坐骨神经肌肉分支、股神经和坐骨神经主分支的束内多电极刺激（IFMS）来刺激后肢肌肉组织。刺激是通过急性或慢性植入犹他倾斜电极阵列（USEAs）实现的，通过电极亚组1)激活髋关节、膝关节和踝关节伸肌的运动单元，2)能够唤起大的伸展力，3)表现出最小的目标运动单元的协同激活。研究人员研究了三种后肢力量产生策略，包括顺序激活独立运动单元来增加力量，以及交错或同时使用三组6个或更多的USEA电极刺激髋关节、膝关节和踝关节伸肌的IFMS。所有的力生成策略都诱发了站立，但与同时激活不同运动神经元池所产生的疲劳相比，交错IFMS策略也减少了重复坐立动作所产生的肌肉疲劳。这些结果表明，使用交错IFMS作为在单侧后肢重建协调、抗疲劳的多关节肌肉力量的一种手段。这种肌肉激活模式可以为因脊髓损伤、中风或疾病瘫痪的个体提供一种有前途的神经假体方法，用于恢复从坐姿到站立的转变。
The production of graceful skeletal movements requires coordinated activation of multiple muscles that produce torques around multiple joints. The work described herein is focused on one such movement, stance, that requires coordinated activation of extensor muscles acting around the hip, knee and ankle joints. The forces evoked in these muscles by external stimulation all have a complex dependence on muscle length and shortening velocities, and some of these muscles are bi-articular. In order to recreate sit-to-stand maneuvers in the anesthetized feline, we excited the hind limb musculature using intrafascicular multielectrode stimulation (IFMS) of the muscular branch of the sciatic nerve, the femoral nerve, and the main branch of the sciatic nerve. Stimulation was achieved with either acutely or chronically implanted Utah Slanted Electrode Arrays (USEAs) via subsets of electrodes 1) that activated motor units in the extensor muscles of the hip, knee, and ankle joints, 2) that were able to evoke large extension forces, and 3) that manifested minimal coactivation of the targeted motor units. Three hind limb force-generation strategies were investigated, including sequential activation of independent motor units to increase force, and interleaved or simultaneous IFMS of three sets of six or more USEA electrodes that excited the hip, knee, and ankle extensors. All force-generation strategies evoked stance, but the interleaved IFMS strategy also reduced muscle fatigue produced by repeated sit-to-stand maneuvers compared with fatigue produced by simultaneous activation of different motor neuron pools. These results demonstrate the use of interleaved IFMS as a means to recreate coordinated, fatigue-resistant multi-joint muscle forces in the unilateral hind limb. This muscle activation paradigm could provide a promising neuroprosthetic approach for the restoration of sit-to-stand transitions in individuals who are paralyzed by spinal cord injury, stroke, or disease.
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影响因子：
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MONSTER, AW;CHAN, H
通讯作者：
CHAN, H
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