Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease.
Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease.
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DOI：
10.1007/s10549-012-2091-8
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发表时间：
2012-07
影响因子：
3.8
通讯作者：
Tamimi, Rulla M.
中科院分区：
文献类型：
--
作者：
Su, Xuefen;Colditz, Graham A.;Collins, Laura C.;Baer, Heather J.;Sampson, Laura A.;Willett, Walter C.;Berkey, Catherine S.;Schnitt, Stuart J.;Connolly, James L.;Rosner, Bernard A.;Tamimi, Rulla M.
在动物研究中，维生素D和钙已被证明对乳腺癌的发展具有保护作用。维生素D和钙在动物研究中起着重要的抗癌作用。初潮和第一胎之间的暴露可能对乳房发育和未来乳腺癌风险很重要。然而，青少年维生素D和钙摄入量与良性乳腺增生病（BBD）（乳腺癌风险增加的标志物）风险之间的关系尚未得到评估。我们在护士健康研究II中检查了这些协会。在1998年完成青少年饮食调查问卷的29,480名妇女中，1991年至2001年期间通过集中病理学审查确定并确认了682例增殖性BBD病例。使用考克斯比例风险回归估计风险比（HR）和95%置信区间（CI），并针对潜在混杂因素进行调整。在青少年维生素D总摄入量和增殖性BBD之间观察到一种提示性的负相关。青春期维生素D摄入量最高五分位数的女性患增殖性BBD的风险比最低五分位数的女性低21%（多变量HR（95% CI）：0.79（0.61，1.01），p趋势= 0.07）。结果基本上是相同的，当分析仅限于前瞻性的情况下（n = 142）诊断后，返回的青少年饮食问卷和独立的成人维生素D摄入量。在对总维生素D进行额外调整后，青少年牛奶总摄入量与增殖性BBD呈正相关（≥3份/天vs.<1份/天HR（95% CI）：1.41（0.91，2.17），p趋势= 0.03）。青春期钙摄入与增殖性BBD无关（p趋势= 0.91）。在青春期摄入维生素D可能在乳腺癌发生的早期阶段很重要。如果这些发现得到证实，可能会为乳腺癌预防提供新的途径和策略。
Vitamin D and calcium have been shown to have protective effects against breast cancer development in animal studies. Vitamin D and calcium play important anticarcinogenic roles in animal studies. Exposures between menarche and first birth may be important in breast development and future breast cancer risk. However, the relations between adolescent vitamin D and calcium intake and the risk of proliferative benign breast disease (BBD), a marker of increased breast cancer risk, have not yet been evaluated. We examined these associations in the Nurses’ Health Study II. Among the 29,480 women who completed an adolescent diet questionnaire in 1998, 682 proliferative BBD cases were identified and confirmed by centralized pathology review between 1991 and 2001. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression and adjusted for potential confounders. A suggestive inverse association was observed between adolescent total vitamin D intake and proliferative BBD. Women in the highest quintile of vitamin D intake during adolescence had a 21% lower risk (multivariate HR (95% CI): 0.79 (0.61, 1.01), p-trend = 0.07) of proliferative BBD than women in the lowest quintile. Results were essentially the same when the analysis was restricted to prospective cases (n = 142) diagnosed after return of the adolescent diet questionnaire and independent of adult vitamin D intake. Adolescent total milk intake was positively associated with proliferative BBD (≥3 servings/day vs. <1 serving/day HR (95% CI): 1.41 (0.91, 2.17), p-trend = 0.03), after additional adjustment for total vitamin D. Calcium intake during adolescence was not associated with proliferative BBD (p-trend = 0.91). Vitamin D intake during adolescence may be important in the earlier stage of breast carcinogenesis. These findings, if corroborated, may suggest new pathways and strategies for breast cancer prevention.
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影响因子：
2.3
作者：
Su, Xuefen;Tamimi, Rulla M.;Colditz, Graham A.
通讯作者：
Colditz, Graham A.
DOI：
10.1158/1055-9965.epi-08-1163
发表时间：
2009-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Berkey CS;Colditz GA;Rockett HR;Frazier AL;Willett WC
通讯作者：
Willett WC
DOI：
10.1093/jnci/51.5.1479
发表时间：
1973-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BUELL, P
通讯作者：
BUELL, P
影响因子：
5
作者：
HISLOP, TG;BAND, PR;LABO, T
通讯作者：
LABO, T
影响因子：
3.8
作者：
Russo, J;Tay, L K;Russo, I H
通讯作者：
Russo, I H