Positive and negative signals between interacting cells for establishing neural fate
Positive and negative signals between interacting cells for establishing neural fate
复制标题
相互作用的细胞之间建立神经命运的正负信号
作者：
Jenny E Rooke;Tian Xu
Specifying multiple cell types from a population of initially equivalent cells is a fundamental process in the development of all multicellular organisms. Neural development in the fruit fly Drosophila melanogaster provides an excellent venue in which to examine mechanisms of cell fate specification. Inhibitory cell–cell interactions mediated by genes of the Notch‐Delta signaling pathway govern the selection of neural and epidermal fates among cells with equivalent developmental potential in a process termed lateral inhibition. Recent data on the roles of genes such as Notch, Delta, and kuzbanian warrant a rethinking of the lateral inhibition model. Furthermore, evidence for a positive signaling pathway promoting the neural fate among equivalent cells suggests that this mechanism acts in addition to lateral inhibition to specify cell fate. A balance of opposing signals may be necessary to correctly partition cells of different types from an initially homogeneous population of cells. BioEssays 20:209‐214, 1998. © 1998 John Wiley & Sons, Inc.
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无毛和无毛抑制因子的拮抗活性控制着果蝇成体表皮中的替代细胞命运。
DOI：
10.1242/dev.120.6.1433
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Schweisguth,F;Posakony,JW
通讯作者：
Posakony,JW
影响因子：
10.5
作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
通讯作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
影响因子：
4.6
作者：
P. J. Kooh;R. Fehon;M. Muskavitch
通讯作者：
P. J. Kooh;R. Fehon;M. Muskavitch
影响因子：
10.5
作者：
CAGAN, RL;READY, DF
通讯作者：
READY, DF
Delta 函数是果蝇刚毛器官确定和形态发生所必需的。
影响因子：
2.7
作者：
Parks,AL;Muskavitch,MA
通讯作者：
Muskavitch,MA