Lipidomic analyses, breast- and formula-feeding, and growth in infants.
Lipidomic analyses, breast- and formula-feeding, and growth in infants.
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DOI：
10.1016/j.jpeds.2014.10.021
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发表时间：
2015-02
影响因子：
5.1
通讯作者：
Dunger, David B.
中科院分区：
文献类型：
--
作者：
Prentice, Philippa;Koulman, Albert;Matthews, Lee;Acerini, Carlo L.;Ong, Ken K.;Dunger, David B.
评估母乳喂养和配方奶粉喂养婴儿的脂质组学差异。我们利用高分辨率质谱法分析了一项代表性出生队列研究中3个月（n = 241）和12个月（n = 144）采集的3.2 mm干血斑样本。比较纯母乳喂养、配方奶喂养或混合喂养婴儿的脂质组学特征，并与12个月婴儿体重相关。数据分析包括多变量监督统计（偏最小二乘判别分析）和单变量分析，并对多重检验进行校正。在纯母乳喂养和配方奶粉喂养的婴儿中，观察到3个月大的脂质组学特征有明显差异；混合喂养的婴儿表现出中等的特征。母乳喂养婴儿的主要脂质学特征是总磷脂酰胆碱（PCs）较低，特别是短链不饱和PC较低，而长链多不饱和PC较高；高胆固醇；以及鞘磷脂的可变差异。在12个月时，脂质组学特征与3个月时明显不同，早期母乳/配方奶粉/混合喂养组之间的差异不再明显。然而，与3个月母乳喂养有关的几种特定脂质种类也与3至12个月体重的差异有关。最先进的干血斑样本脂质组学分析显示母乳喂养和配方奶粉喂养婴儿之间的显著差异。尽管这些变化随着年龄的增长而减弱，但母乳喂养3个月时的脂质组学特征与婴儿体重有关，可能代表婴儿营养的生物标志物。
To evaluate lipidomic differences between breast- and formula-fed infants. We utilized high-resolution mass-spectrometry methods to analyze 3.2 mm dried blood spot samples collected at ages 3 months (n = 241) and 12 months (n = 144) from a representative birth cohort study. Lipidomic profiles were compared between infants exclusively breast-fed, formula-fed, or mixed-fed, and related to 12-month infancy weight. Data analysis included supervised multivariate statistics (partial least squares discriminant analysis), and univariate analysis with correction for multiple testing. Distinct differences in 3-month lipidomic profiles were observed between exclusively breast-fed and formula-fed infants; mixed-fed infants showed intermediate profiles. Principle lipidomic characteristics of breast-fed infants were lower total phosphatidylcholines (PCs), with specifically lower short chain unsaturated PC but higher long chain polyunsaturated PC; higher cholesterol esters; and variable differences in sphingomyelins. At 12 months, lipidomic profiles were markedly different to those at 3 months, and differences between the earlier breast/formula/mixed-feeding groups were no longer evident. However, several specific lipid species, associated with breast-feeding at 3 months, also correlated with differences in 3- to 12-month weight. State-of-the-art dried blood spot sample lipidomic profiling demonstrated striking differences between breast-fed and formula-fed infants. Although these changes diminished with age, breast-fed lipidomic profiles at 3 months were associated with infancy weight and could potentially represent biomarkers of infant nutrition.
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影响因子：
1.7
作者：
Tanaka, K.;Hosozawa, M.;Shimizu, T.
通讯作者：
Shimizu, T.
影响因子：
7.1
作者：
Ong, Ken K.;Langkamp, Markus;Dunger, David B.
通讯作者：
Dunger, David B.
DOI：
10.1097/00005176-200005000-00015
发表时间：
2000-05-01
影响因子：
2.9
作者：
Decsi, T;Kelemen, B;Kohn, G
通讯作者：
Kohn, G
DOI：
10.1097/00005176-199108000-00004
发表时间：
1991-08-01
影响因子：
2.9
作者：
JOOSTE, PL;ROSSOUW, LJ;CHARLTON, DO
通讯作者：
CHARLTON, DO
DOI：
10.2174/1874288220131127003
发表时间：
2013-01-01
期刊：
The Open Nutrition Journal
影响因子：
--
作者：
Oleynik, A.;Eliseeva, T.;Vanderhoek, J. Y.
通讯作者：
Vanderhoek, J. Y.