Pathogenic analysis of Borrelia garinii strain SZ isolated from Northeastern China.
Pathogenic analysis of Borrelia garinii strain SZ isolated from Northeastern China.
复制标题
东北地区伯氏疏螺旋体SZ株的病原学分析
DOI：
10.1186/1756-3305-6-177
复制
发表时间：
2013-06-17
影响因子：
3.2
通讯作者：
Yin H
中科院分区：
文献类型：
--
作者：
Wu Q;Liu Z;Wang J;Li Y;Guan G;Yang J;Chen Z;Luo J;Yin H
背景
广义伯氏疏螺旋体（Borrelia burgdorferi sensu lato（s.l.）已经从世界各地的病人和动物身上鉴定出来。基因种相关的疾病传播已有报道。本研究旨在阐明B引起的感染的致病性。在中国分离到garinii SZ。B。burgdorferiB 31和B. B. Afzelii B 0 23用于比较。
方法
通过基于小沟结合剂的实时聚合酶链反应测量感染小鼠的血液和组织样品中的螺旋体载量。在BALB/c小鼠中评估螺旋体传播的动力学和疾病严重程度。
结果
三种基因种之间的细菌负荷模式不同。B。SZ株具有高致病性，可引起小鼠多系统病理损害。
结论
螺旋体的传播、持久性、组织嗜性和疾病严重程度存在显著差异，表明不同基因种可能在临床疾病的致病性和发展中起重要作用。
Background
Various genospecies of Borrelia burgdorferi sensu lato (s.l.) have been identified from patients and animals worldwide. Genospecies-related dissemination of disease has been reported. The present study aimed to elucidate the pathogenicity of infections caused by B. garinii SZ isolated in China. B. burgdorferi B31 and B. afzelii BO23 were used for comparison.
Methods
Spirochete load in blood and tissue samples of infected mice were measured by minor groove binder-based real-time polymerase chain reaction. The kinetics of spirochete dissemination and disease severity were assessed in BALB/c mice.
Results
The pattern of bacterial load differed between the three genospecies. The B. garinii SZ strain is highly pathogenic and can trigger multi-system pathological damage in mice.
Conclusions
Spirochete dissemination, persistence, tissue tropism and disease severity varied significantly, suggesting that different genospecies may play an important role in the pathogenicity and development of clinical diseases.
登录
查看更多内容
影响因子：
--
作者：
CANICA, MM;NATO, F;POSTIC, D
通讯作者：
POSTIC, D
影响因子：
3.2
作者：
Scholz, Holger C.;Margos, G.;Fingerle, V.
通讯作者：
Fingerle, V.
影响因子：
14.2
作者：
Stanek, G.;Fingerle, V.;Gray, J.
通讯作者：
Gray, J.
影响因子：
2.1
作者：
Bonnet, S.;de la Fuente, J.;Joncour, G.
通讯作者：
Joncour, G.
影响因子：
2.1
作者：
Rudenko, Nataliia;Golovchenko, Maryna;Grubhoffer, Libor
通讯作者：
Grubhoffer, Libor