Memory Modulation by Exercise in Young Adults Is Related to Lactate and Not Affected by Sex or BDNF Polymorphism.
Memory Modulation by Exercise in Young Adults Is Related to Lactate and Not Affected by Sex or BDNF Polymorphism.
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体育锻炼对健康和认知的益处已得到广泛认可。然而，对认知改善负责的运动特征及其潜在机制仍有待阐明。为了解决这些问题，我们的研究比较了年轻人在两种不同的运动模式后的认知结果。具体来说，我们研究了高强度间歇运动（HIIE）和中等强度连续运动（MIE）在视觉空间和陈述性记忆方面的差异，考虑了运动相关参数（如乳酸释放）和不可改变因素（包括BDNF多态性和生物性别）的影响。我们的研究结果表明，运动强度和强度依赖性乳酸释放在调节运动后认知改善方面具有相关性，而与上述不可改变因素无关。这些数据表明，应该仔细考虑运动的特点和强度，以优化年轻人的认知反应。相反，对基因型和生理性别的考虑是微不足道的。目前，高强度间歇运动（HIIE）与中等强度运动（MIE）相比呈上升趋势，因为它们在低时间要求下对健康和表现有相似的益处。最近的研究表明，体育锻炼也可以影响认知功能，尽管最佳剂量和潜在机制尚不清楚。因此，在我们的研究中，我们比较了不同运动强度（HIIE和MIE）对视觉空间和陈述性记忆的影响，包括可能的相关因素，如每次运动后乳酸释放和脑源性神经营养因子（BDNF）基因型。36名大学生参与了本研究。HIIE阶段包括3分钟热身，4组2分钟，以90-95%的最大有氧速度（MAS）进行，两组之间有2分钟的被动恢复，3分钟冷却，MIE阶段意味着以60%的MAS连续运动的总时间相同。在视觉空间记忆测试的逆向条件下（p = 0.014, ηp2 = 0.17）和陈述性记忆测试的48 h保留（p = 0.04, d = 0.34）， HIIE后的改善明显优于MIE。视觉空间记忆测验的前向状态和陈述性记忆测验的7天保留在两组间无显著差异（p < 0.05）。此外，生理性别和BDNF多态性（Val/Val、Val/Met或Met/Met）等不可改变的参数并不能调节对运动的认知反应。奇怪的是，相关分析显示记忆（视觉空间和陈述性）的变化与乳酸释放之间存在关联（p < 0.05）。从这个意义上说，我们的研究结果表明，无论生物性别或BDNF Val66Met多态性等遗传因素如何，运动强度在改善运动认知功能方面都起着重要作用。
The health and cognitive benefits associated with physical exercise are widely acknowledged. However, exercise characteristics responsible for the improvement in cognition, along with the underlying mechanisms, remain to be elucidated. In an attempt to resolve these questions, our study compares cognitive outcomes after two distinct exercise modes in young adults. Specifically, we have examined the differences between high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MIE) on visuospatial and declarative memory, contemplating the influence of exercise-associated parameters such as released lactate and non-modifiable factors, including BDNF polymorphism and biological sex. Our results demonstrate the relevance of exercise intensity and intensity-dependent lactate release in modulating cognitive improvement following exercise with no association with the non-modifiable factors mentioned above. These data suggest that the exercise characteristics and intensity of exercise sessions should be carefully considered to optimize cognitive response in young adults. Conversely, the consideration of genotype and biological sex is inappreciable. Currently, high-intensity interval exercise (HIIE) is on the rise compared to moderate-intensity exercise (MIE) due to its similar benefits for health and performance with low time requirements. Recent studies show how physical exercise can also influence cognitive function, although the optimal dose and underlying mechanisms remain unknown. Therefore, in our study, we have compared the effects on visuospatial and declarative memory of different exercise intensities (HIIE vs. MIE), including possible implicated factors such as lactate released after each session and the Brain-Derived Neurotrophic Factor (BDNF) genotype. Thirty-six undergraduate students participated in this study. The HIIE session consisted of a 3 min warm-up, four 2 min sets at 90–95% of the maximal aerobic speed (MAS) with 2 min of passive recovery between sets, and a 3 min cooldown, and the MIE session implies the same total duration of continuous exercise at 60% of the MAS. Better improvements were found after HIIE than MIE on the backward condition of the visuospatial memory test (p = 0.014, ηp2 = 0.17) and the 48 h retention of the declarative memory test (p = 0.04; d = 0.34). No differences were observed in the forward condition of the visuospatial memory test and the 7-day retention of the declarative memory test (p > 0.05). Moreover, non-modifiable parameters such as biological sex and BDNF polymorphism (Val/Val, Val/Met, or Met/Met) did not modulate the cognitive response to exercise. Curiously, the correlational analysis showed associations (p < 0.05) between changes in memory (visuospatial and declarative) and lactate release. In this sense, our results suggest an important role for intensity in improving cognitive function with exercise, regardless of genetic factors such as biological sex or BDNF Val66Met polymorphism.
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影响因子：
4.1
作者：
Hashimoto T;Tsukamoto H;Ando S;Ogoh S
通讯作者：
Ogoh S
影响因子：
3.8
作者：
Herold, Fabian;Muller, Patrick;Muller, Notger G
通讯作者：
Muller, Notger G
影响因子：
2.1
作者：
Antonia Sanchez-Romero, Maria;Dorado, Pedro;Llerena, Adrian
通讯作者：
Llerena, Adrian
DOI：
10.1073/pnas.0810650105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Izquierdo, Ivan;Bevilaqua, Lia R.;Cammarota, Martin
通讯作者：
Cammarota, Martin
影响因子：
4
作者：
Crispim Nascimento, Carla Manuela;Pereira, Jessica Rodrigues;Stella, Florindo
通讯作者：
Stella, Florindo