How do cells regulate redox environment at the subcellular level?

大多数生物体生活在有氧环境中，使其细胞受到活性氧的影响。 活性氧物质被认为是导致衰老的原因，在许多疾病中，氧化和还原条件（氧化还原环境）之间的平衡受到干扰。 这项研究将确定不同的细胞结构如何感知和维持这种氧化还原稳态，不仅在整个细胞中，而且在细胞中的不同细胞器中。 这项工作将有助于确定哪些细胞区室和过程在不同的疾病状态下受到影响，并对细胞如何协调其不同的细胞器以维持氧化和还原条件之间的平衡提供基本的理解。

Most organisms live in an aerobic environment that subjects their cells to reactive oxygen species. Reactive oxygen species have been proposed to lead to ageing, and in many diseases the balance between oxidising and reducing conditions (the redox environment) is perturbed. This research will identify how different cellular structures sense and maintain this redox homeostasis, not just in the whole cell, but within the different organelles in the cell. The work will help identify which cell compartments and processes are affected in different disease states and provide a fundamental understanding of how cells coordinate their different organelles to maintain the balance between oxidising and reducing conditions.