Defining in molecular terms cis-inhibition as a means to inhibit Notch signaling

婴儿的正常发育和我们出生后的健康取决于我们的细胞的行为。信号在细胞之间和细胞内部移动，告诉它们该做什么。与其他蛋白质相互作用的蛋白质主要传递这些信号。这项研究的重点是一种名为Notch的蛋白质及其传递的信号。Notch在正常过程中起作用，例如血管形成;但异常信号传导导致和/或促成病理情况，例如退行性疾病和癌症。我们正在努力了解Notch信号是如何产生的，以及如何在异常时控制它。这将允许开发新的药物来帮助患有癌症和其他Notch相关疾病的人

Normal development of a baby and our health after birth is dependent on how our cells behave. Signals move between cells and within them to tell them what to do. Proteins interacting with other proteins mostly transmit these signals. This research focuses on a protein named Notch and the signals that it transmits. Notch functions in normal processes, such as blood vessel formation; but abnormal signaling causes and/or contributes to pathological situations such as degenerative disease and cancer. We are working to understand how the Notch signal is made and how to control it when it is abnormal. This will allow new medications to be developed to help people who have cancer and other Notch-related illnesses