Metal complex-aminoglycoside conjugates for sequence-specific cleavage of ribonucleic acid (RNA)

在寻找抗击艾滋病毒/艾滋病等疾病的新方法时，核糖核酸(RNA)正成为越来越有吸引力的药物靶标。该项目将通过开发能够裂解细菌和逆转录病毒中发现的RNA分子的新化合物，帮助澳大利亚处于RNA-药物相互作用领域研究发展的前沿。除了将有助于未来新药开发的宝贵知识体系外，该项目还将为新兴医疗和生物技术行业、研究机构和大学热衷于寻求的年轻科学家提供高质量的多学科培训。

Ribonucleic acid (RNA) is emerging as an increasingly attractive drug target in the search for new approaches to combat diseases such as HIV/AIDS. This project will help position Australia at the forefront of research developments in the field of RNA-drug interactions, through the development of novel compounds that can cleave RNA molecules found in bacteria and retroviruses. In addition to a valuable body of knowledge that will assist in the future development of new drugs, this project will provide high quality multi-disciplinary training for young scientists keenly sought by emerging medical and biotechnological industries, research organisations and universities.