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The IL23 Receptor (IL23R) regulates mitotic spindle formation and is a novel therapeutic target for AML

The IL23 Receptor (IL23R) regulates mitotic spindle formation and is a novel therapeutic target for AML
IL23 受体 (IL23R) 调节有丝分裂纺锤体的形成,是 AML 的新型治疗靶点
批准号:
483377
负责人:
Schimmer Aaron D
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-03-01 至 2024-03-01

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中文摘要
翻译
包括AML细胞在内的癌细胞通常具有异常数量的染色体。这种异常的遗传物质导致癌症,但在癌细胞必须分裂时也给癌细胞带来压力。癌细胞找到了适应这种环境的机制
英文摘要
Cancer cells, including AML cells, often have abnormal numbers of chromosomes. This abnormal genetic material leads to cancer, but also presents a stress to the cancer cell when the cancer cell must divide. Cancer cells find mechanisms to adapt to this st
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Improved treatments of Acute Myeloid Leukaemias by Personalized Medicine
  • 批准号:
    387780
  • 项目类别:
    Operating Grants
  • 资助金额:
    $32.78万
  • 财政年份:
    2018
  • 负责人:
    Schimmer Aaron D
  • 依托单位:
Developing new therapeutic strategies for AML (Acute Myeloid Leukemia)
  • 批准号:
    354022
  • 项目类别:
    Operating Grants
  • 资助金额:
    $242.84万
  • 财政年份:
    2016
  • 负责人:
    Schimmer Aaron D
  • 依托单位:
Targeting mitochondrial protein folding in the inter-membrane space as a novel therapeutic strategy for AML
  • 批准号:
    354325
  • 项目类别:
    Operating Grants
  • 资助金额:
    $52.94万
  • 财政年份:
    2016
  • 负责人:
    Schimmer Aaron D
  • 依托单位:
Targeting the mitochondrial proteasome, ClpP, in AML
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