Hypoxemia in the Tibetan Autonomous Region of China

这笔拨款允许比尔博士在中华人民共和国西藏自治区帕拉进行人类生物学研究。大约有170名男女游牧民（年龄在15岁之间）。85)待研究的地区居住在海拔4900英尺之间的高海拔地区。海拔5450米，这个项目的目标是了解人们如何适应在这样的高度全年居住。比尔医生会测量血红蛋白浓度分布，动脉血氧饱和度百分比和通气情况。研究参与者将提供手指采集的血液样本进行血液学分析，并进行无创血氧测定。静息通风量也将被测量。这将产生关于这些参数中年龄和性别差异的基本流行病学数据，并允许beall博士检验血红蛋白浓度和动脉氧饱和度百分比之间存在负相关的假设。比尔博士还假设，动脉血氧饱和度和通气之间存在正相关关系。这是一个非常有趣的研究对象，因为它们常年生活在如此高的海拔。这也很有趣，因为西藏人对高海拔带来的氧气压力的适应似乎与生活在安第斯山脉的南美人不同。后一组表现为桶状胸，血红蛋白浓度较高。这项研究很重要，因为它将增加我们对人类如何适应身体压力的理解。它可能有助于控制高原反应，并将有助于向美国研究人员开放这个世界上非常有趣的地区。我

This grant permits Dr. Beall to conduct human biological research in Phala, Tibet Autonomous Region, Peoples Republic of China. The approximately 170 male and female nomads (between the ages of 15 .85) to be studied reside at high altitudes of between 4900 . 5450 m above sea level and the goal of this project is to understand how people adapt to year round habitation at such heights. Dr. Beall will measure the distribution of hemoglobin concentration, percent arterial oxygen saturation and ventilation. Study participants will provide fingerstick blood samples for hematological analysis and undergo noninvasive oximetry. Resting ventilation volumes will also be measured. This will yield basic epidemiologic data on age and sex differences in these parameters and allow Dr. beall to test the hypothesis that an inverse association exists between hemoglobin concentration and percent arterial oxygen saturation. Dr. Beall also hypothesiszes that there is a positive association between the percent of arterial oxygen saturation and ventilation. This is an extremely interesting study population because it resides year round at such a high altitude. It is also interesting because it appears that Tibetians adapt to the oxygen stress imposed by high altitude differently from South Americans who live in the Andes. This latter group exhibit barrel chests and higher levels of hemoglobin concentration. These features appear to be abscent in Tibetans. This research is important because it will increase our understanding of how humans adapt to physical stress. It may aid in the management of altitude sickness and will help to open this extremely interesting part of the world to U.S. reseachers. I