Computer for Ultrastructure Research and Molecular Biology

这组结构生物学的研究人员利用传统的电子显微镜和计算机断层扫描与高压电子显微镜相结合。这些项目的基于计算机的组件依赖于栅格图形、大磁盘空间和内存的可用性。这笔赠款资助的设备包括DEC和SUN计算机硬件，这些硬件将提供高速计算能力。使用共享工具是适当的，因为内部开发的大部分现有软件都是为了适应广泛的应用程序而编写的，而且共享设施可以最有效地利用资源。细胞及其亚结构成分的可视化一直是并将继续是现代生物学的重要目标之一。电子显微镜提供了足够强大的放大能力，以成像细胞细胞器和大分子复合体。连续切片的复杂三维重建是由计算机完成的，提供了这些复合体的图像。用电子显微镜和高压电子显微镜研究的结构包括核糖体、膜通道、有丝分裂装置的组成部分和纤毛。

This group of investigators in structural biology utilize the conventional electron microscope and computer tomography in association with the high-voltage electron microscope. The computer-based components of these projects rely on the availability of raster graphics, large disk space, and memory. The funded equipment of this grant consists of DEC and SUN computer hardware which will provide high speed computing capability. The use of shared instrumentation is appropriate because the bulk of existing software developed in-house has been written with a view towards accommodating a wide range of applications, and because a shared facility leads to the most efficient use of resources. Visualization of the cell and its substructural components has been and continues to be one of the important goals of modern biology. Electron microscopy provides magnification powerful enough to image cellular organelles and macromolecular complexes. The complex 3-dimensional reconstruction of serial sections is performed by computer, providing a picture of these complexes. Structures to be investigated by electron microscopy and high voltage electron microscopy include ribosomes, membrane channels, components of the mitotic apparatus, and cilia.