US-Argentina Cooperative Research on Studies on the Mechanism of Action of Aldosterone in Brain

该奖项支持洛克菲勒大学的Bruce McEwen博士和阿根廷布宜诺斯艾利斯生物和实验医学研究所的Alexandro de Nicola博士在神经内分泌学方面的合作研究。这项工作将确定大脑中类固醇激素的两个受体系统的特征和重叠程度。了解类固醇受体之间的通讯对于解释其他神经递质和受体之间的相互作用很重要。新的分子生物学方法的使用将导致脑神经科学的新进展。主要研究人员以前有过成功合作的历史，德尼古拉博士的前学生科里尼博士现在是麦克尤恩博士实验室的博士后。这两个实验室都有很好的设备进行各自的研究，因此双方在研究糖皮质激素对盐皮质激素受体的调节和盐皮质激素受体对糖皮质激素受体的调节方面都可以做出重大贡献。此外，这些激素的水平以及结合活性如何受到监管的影响也将得到确定。这项工作将继续进行富有成效的四年合作。

This award supports cooperative research in neuroendocrinology between Dr. Bruce McEwen of the Rockefeller University and Dr. Alexandro De Nicola at the Institute of Biology and Experimental Medicine in Buenos Aires, Argentina. This work will identify the characteristics of and the degree of overlap between two receptor systems for steroid hormones in the brain. Understanding the communication between steroidal receptors is important to interpreting interactions between other neurotransmitters and receptors. The use of new molecular biological methodology will lead to new advances in brain neuroscience. The principal investigators have a history of previous successful collaboration and a former student of Dr. De Nicola, Dr. Coirini, is now a post-doc in Dr. McEwen's laboratory. Both laboratories are well equipped for their part of the research and therefore significant contributions can be made by both sides in investigating the regulation of mineralocorticoid receptors by glucocorticoids and the regulation of glucocorticoid receptors by mineralocorticoids. Also, the levels of these hormones and how the binding activity is affected by the regulation will be determined. This work will continue a productive four-year collaboration.