Antiinsectan Natural Products from Fungal Sclerotia

合成有机化学项目支持詹姆斯·格洛尔博士的工作。Gloer是爱荷华大学的化学助理教授，他正在从真菌中寻找新颖的生物活性化合物。Gloer已经在真菌菌核中发现了天然产物的新来源，这是一种与真菌有关的生理结构，而其他天然产品化学家一直忽视了这一点。植物病原真菌和储藏真菌的菌核提取物将进行昆虫拒食活性测试。活性样品将被层析，以找到提取物的活性成分。将对分离出的新化合物进行结构分析。对这些新代谢物来源的检查将集中在产生这些化合物的特殊真菌生理结构上，以产生关于这些化合物在自然界中的起源和生物学意义的基本新知识。

The Synthetic Organic Chemistry program supports the work of Dr. James Gloer. Gloer, an assistant professor of chemistry at the University of Iowa, is looking for novel and biologically active compounds from fungi. Gloer has identified a new source of natural products in fungal sclerotia, physiological structures associated with fungi that have been overlooked by other natural products chemists. Sclerotial extracts from plant pathogenic and stored-product fungi will be tested for insect antifeedant activity. Active samples will be chromatographed to find the active components of the extracts. Structure analysis will be performed on the new compounds isolated. Examination of the source of these new metabolites will focus on the particular fungal physiological structure that produces the compounds in order to generate fundamental new knowledge on the origins and biosignificance of these compounds in Nature.