Organic Ion-Molecule Chemistry

这个奖项是在有机动力学项目中颁发的，以支持明尼苏达大学史蒂文·卡斯博士的研究。利用变温流动余辉（FA）技术研究了有机离子分子的气相反应。要研究的主要反应将是单分子重排、消除反应和新阴离子的产生和表征。将得到由酸碱化学生成的气相烷基阴离子的取代效应、热力学性质、反应性和碳-碳键裂解。各种开环，质子和烷基移位和协同反应将被研究。通过测量速率系数作为温度的函数，可以得到活化能。探讨烷基卤化物与碱反应中的取代与消除反应，并研究1,2-和1,4-消除反应的首选立体化学。这些研究的目的是为结构和反应性之间的关系提供一个更好的认识。

This award is made in the Organic Dynamics Program in support of the research of Dr. Steven Kass at the University of Minnesota. The research is concerned with the gas-phase reactions of organic ion-molecules as studied by the variable temperature Flowing Afterglow(FA) technique. The principal reactions to be studied will be unimolecular rearrangements, elimination reactions and the generation and characterization of novel anions. Substituent effects, thermodynamic properties, reactivities and carbon-carbon bond cleavages of gas-phase alkyl anions, generated by acid-base chemistry, will be obtained. A variety of ring-openings, proton and alkyl shifts and concerted reactions will be studied. Activation energies will be obtained by measuring rate coefficients as a function of temperature. Substitution versus elimination in the reaction of alkyl halides with bases will be explored and the preferred stereochemistry in 1,2- and in 1,4-eliminations will be studied. The objective of these studies is to provide a greater appreciation for the relationship between structure and reactivity.