Metal Complex Catalyzed Base Sequence Dependent RNA Hydrolysis

妇女研究机会计划奖助金是在生物无机化学领域。从1989年5月15日开始的12个月内，珍妮特·莫罗教授将对锌(II)催化的磷酸二酯的水解进行初步实验，这些磷酸酯是生物重要分子的模型。这些实验将与一名本科生和一名研究生合作进行，应该提供首席调查员制定有竞争力的全面研究方案所需的初步数据，并导致在她位于布法罗的纽约州立大学的实验室建立一个可行的、独立的研究计划。本项目将探索的研究领域在生物化学中具有广泛的重要性，特别是在核糖核酸(RNA)的表征方面。这项工作的结果可能会导致新的RNA测序试剂的开发。

This Research Opportunities for Women Research Planning Grant is in the area of bioinorganic chemistry. During the twelve month period beginning 15 May 1989, Professor Janet Morrow will conduct preliminary experiments on the Zn(II) catalyzed hydrolysis of phosphate diesters that are models for biologically important molecules. These experiments, which will be conducted collaboratively with one undergraduate and one graduate research student, should provide the preliminary data that is necessary for the Principal Investigator to develop a competitive full research proposal and lead to the establishment of a viable, independent research program in her laboratory at SUNY at Buffalo. The research area that is to be explored in this project is broadly important in biological chemistry, particularly in the characterization of ribonucleic acids (RNAs). The results of this work could lead to the development of new reagents for RNA sequencing.