Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics

该项目旨在开发一套集成机械和生物传感器的可移动微/纳米结构，它将与细胞连接，以研究这些细胞如何对周围的物理环境做出反应。预期的结果是微/纳米制造、传感和先进成像的新技术，以及对控制组织形成和修复的生物过程的深刻理解。这些结果将影响3D微系统的开发和应用，为先进的体外细胞培养系统的设计提供信息。在3D纳米微工程和产生支持干细胞和组织工程技术未来进步的新知识方面，预计会有显著的好处。

This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repair. These outcomes would impact how 3D microsystems are developed and applied, informing the design of advanced in-vitro cell culture systems. Significant benefits are expected in 3D nano-microengineering, and in generating new knowledge underpinning future advances in stem cell and tissue engineering technologies.